Swertiamarine

For Research Use Only.
Category
Phenols
Cat.No.
NP4611
CAS
55481-88-4
Product Name
Swertiamarine
Structure

Product Details

Description
Mollugin, which can be extracted from the roots of Rubia cordifolia L, could be a novel therapeutic candidate for bone loss-associated disorders including osteoporosis, rheumatoid arthritis, and periodontitis. It is a novel modulator of the HER2 pathway in HER2-overexpressing cancer cells with a potential role in the treatment and prevention of human breast and ovarian cancer with HER2 overexpression. Besides, Mollugin may be a JAK2 inhibitor and inhibits LPS-induced inflammatory responses by blocking the activation of the JAK-STAT pathway.
Synonyms
Rubimaillin; 2H-Naphtho[1,2-b]pyran-5-carboxylic acid; 6-hydroxy-2, 2-dimethyl-, methylester; 2,2-Dimethyl-6-hydroxy-2H-naphtho[1,2-b]pyran-5-carboxylic acid methyl ester; 6-Hydroxy-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5-carboxylic acid methyl ester; Methyl 6-hydroxy-2,2-dimethylbenzo[h]chromene-5-carboxylate; MOLLUGIN(SH)
Molecular Weight
284.3
Molecular Formula
C17H16O4
Boiling Point
453.2±45.0 °C(Predicted)
Melting Point
132~134 °C
Purity
>98%
Density
1.239±0.06 g/cm3(Predicted)
Solubility
Chloroform (Slightly), Ethyl Acetate (Slightly)
Appearance
Cryst.
Application
Anticancer
Storage
2-8°C
Color
Yellow to Green
EINECS
683-209-5
Form
Solid
HS Code
29329990
pKa
8.40±0.40(Predicted)
Safety Statements
24/25
Uses
Mollugin is an anti-tumor agent inducing apoptosis and autophagy in various cancer models.
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