Structural Modification Services of Natural Products

Structural Modification Services of Natural Products

The complex molecular structure of natural products endows them with unique physiological activities and is a treasure house for the development of many new drugs. Natural products in nature usually have complex structure, high toxicity and side effects, poor solubility, weak activity and other defects, it is difficult to produce drugs, it needs to be modified by chemical method or biological transformation method. The structure of natural products is simplified, which is conducive to artificial large-scale synthesis. Eliminate unnecessary chiral center, can reduce the toxic side effects; Solubility and activity can be improved by introducing solubilization groups or other functional structure fragments. The structure modification of natural products can greatly improve the rate of drug preparation and accelerate the process of new drug research and development.


  • Chemical method

Chemical method is to determine pharmacophore through activity test and structure-activity relationship study, and optimize the structure of other pharmacophore, such as alkylation, acylation, sulfonation, phosphorylation, etc.

  • Biological transformation method

Biological transformation is the use of microorganisms or enzymes produced by them to modify the structure of natural products. Currently, this method has involved a variety of reaction types such as glycosylation, hydroxylation, epoxidation, methylation, isomerization, esterification, hydrolysis and rearrangement.

Our Services

BOC Sciences provides clients with structural modification services for natural products to facilitate the development of natural product products and facilitate the faster development of pharmaceutical products.

Service contents

BOC Sciences can provide you with natural products and alkylation, fluorination, glycosylation and other synthetic reagents to assist in the study of natural product structure modification. In addition, we can also provide you with other types of product modification services in addition to the above service content. Our technical team is constantly innovating and looking for new techniques to complete the modification of natural products. Please continue to pay attention to us, we will provide you with the products and services you want.

If you have a requirement about our services, please contact us by phone or email, our colleagues will reply to you within three working days.

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