BOC Sciences offers chemical modification methods for natural products including acetyl methyl peroxide, acetylation and glycosylation. Structural modification of natural products not only increases structural diversity, but also improves activity and bioavailability. Among them, the use of carbohydrate as the sugar base donor for structural modification has a significant effect on improving solubility and antitumor activity. Glycosylation of natural products and drugs can often effectively change the physical and chemical activities of the parent molecules, so the use of carbohydrate groups to glycosylation of natural products is an important means of new drug development. We are good at helping customers to develop natural products from various fields, and help customers to better and faster use products in medicine, daily chemicals and other industries.
Due to their unique chemical structures, natural products have a variety of unique pharmacological activities. Many natural products have been proven to have many activities such as anti-inflammatory and anti-bacterial, anti-viral, antioxidant, anti-malignant, anti-laser radiation and modulation of human immune function, and have been successfully developed for clinical applications. However, only a small percentage of natural products are directly used for the treatment of diseases without modification. This is due to the deficiencies in the physicochemical properties of most natural products, such as solubility and bioavailability, which lead to insufficient druggability; in addition, low pharmacological activity or excessive adverse effects are another major reason why natural products cannot be directly applied to clinical treatment. Through structural modification, we can improve the physicochemical properties, biological activity and reduce the adverse effects of natural products.
BOC Sciences' chemistry and biology experts modify the structure of glycosyl side chains, thereby affecting the biological activity, substrate suitability and pharmacological properties of the parent compound. Using chemical and enzymatic methods, our researchers have developed a variety of natural product glycosylation modifications to help our clients better develop the medicinal properties of their natural products.
Monosaccharides must undergo nucleoside monophosphorylation (NMP) or nucleoside diphosphorylation (NDP) before they can be utilized.
Glycosyltransferases are key enzymes in the glycosylation process, catalyzing the reaction of NDP sugars and glycosidic ligands to attach glycosyl groups to the N (N-linked glycosylation), O (O-linked glycosylation) or C (C-linked glycosylation), and S (S-linked glycosylation) of the acceptor to complete glycosylation.
The modification methods are combinatorial biology, GTs modification, in vitro glycan randomization, novel glycan randomization, and glycosyl side chain modification using the reversibility of GTs.
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