BOC Sciences provides professional natural product activity screening services, which currently include anti-tumor and anti-inflammatory drug activity screening, neurological drug activity screening, cardiovascular drug activity screening, metabolic disease drug activity screening, dermocosmetic and antibacterial drug activity screening. We can provide activity screening services at molecular level, cellular level and animal level to provide technical support for new drug discovery and pharmacological research.
This kind of activity screening mainly uses in vitro tumor cell lines to detect the inhibitory effect of natural compounds on cell survival, which has the advantages of low cost, rapid detection and suitable for high throughput. Meanwhile, we keep tracking the latest anti-tumor specific targets and establish screening models to provide important clues for obtaining novel anti-tumor natural drugs from natural products with high specificity, strong targeting and low toxic side effects.
The activity screening utilized macrophages from mice to detect the inhibitory effect of the compounds on NO production. When immune cells are stimulated by microbial endotoxins and inflammatory mediators, they produce large amounts of inducible nitric oxide synthase to generate NO for immune response. Therefore, inhibition of NO production is a direct indicator of the anti-inflammatory activity of the compound.
Neurological drug activity screening is aimed at early detection of active compounds in neurodegenerative diseases such as Alzheimer's disease. Currently, acetylcholinesterase inhibitor screening, butyrylcholinesterase inhibitor screening, PC12 cell differentiation promotion activity screening and cytosolic calcium flow activity screening can be performed.
Cardiovascular system activity screening is closely focused on major diseases such as thrombosis and stroke, and can be performed for compound anticoagulation activity screening, anti-platelet aggregation activity screening, anti-washed platelet aggregation activity screening, platelet activation assay, washed platelet activation assay, and platelet activation marker assay.
Metabolic disease drug activity screening is currently running for glucose uptake by adipocytes related to diabetes, DPP-4 inhibitor screening, and lipase inhibitor screening related to the treatment of obesity.
Preliminary evaluation of compounds for skin cytotoxicity, antioxidant, whitening, and anti-aging efficacy can be performed.
We can test compounds for their antifungal and antibacterial activities, thus providing a basis for the development of antibacterial drugs, daily chemical products, food and health products, etc.
In addition to the above screening services, we are continuously building novel, personalized, customized, and high-throughput experimental models to meet the needs of drug screening and pharmacological research.
BOC Sciences' screening technology for diversified and functional assays at the cellular level can simultaneously detect the effects of the natural product being screened on multiple aspects of cell growth, differentiation, migration, apoptosis, metabolic pathways and signal transduction, and obtain a large amount of relevant information from a single experiment to determine its biological activity and potential toxicity. High-interest screening is an effective complement to traditional high-throughput screening, enabling researchers to obtain detailed data on the multiple effects of active compounds on cells, including cytotoxicity, metabolic regulation and non-specific effects on other targets, at an early stage of new drug research, which can significantly increase the rate of discovery of lead compounds and the success rate of late drug development.
If you have a requirement about our services, please contact us by phone or email, our colleagues will reply to you within three working days.