Polyphyllin VI

Steroids

NP6115

55916-51-3

Polyphyllin VI

Polyphyllin VI is a natural product derived from the rhizomes of Paris yunnanensis Franch, which is traditionally used in Chinese medicine. It is known for its various bioactivities, including hemostasis, expectorant, bacteriostasis, anticytotoxic, anti-pregnancy, and sperm-killing effects. Recent studies have shown that Polyphyllin VI exhibits significant antitumor activity, particularly against non-small cell lung cancer (NSCLC), by inducing apoptosis and autophagy both in vitro and in vivo. It has also been reported to inhibit cell proliferation by causing G2/M phase arrest and to induce apoptosis and autophagy through ROS/JNK activation in certain cell types. Additionally, Polyphyllin VI has been shown to have analgesic and anti-inflammatory effects, relieving inflammatory pain by inhibiting inflammation and normalizing the expression of P2X3 purinoceptors.

17-Hydroxyparis V; Polyphyllin F (Polyphyllin VI); Polyphyllin Ⅵ; (3β,25R)-17-Hydroxyspirost-5-en-3-yl 2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside; Paris saponin VI; Paris VI; Pennogenin 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside; Pennogenin-3-O-α-L-rhamnopyranosyl(1→2)-β-D-glucoside; Polygonatoside B3; Saponin Tb

(2S,3R,4R,5R,6S)-2-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-[(1R,2S,4S,5'R,6R,7S,8S,9S,12S,13R,16S)-8-hydroxy-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-16-yl]oxyoxan-3-yl]oxy-6-methyloxane-3,4,5-triol

738.91

C39H62O13

CC1CCC2(C(C3(C(O2)CC4C3(CCC5C4CC=C6C5(CCC(C6)OC7C(C(C(C(O7)CO)O)O)OC8C(C(C(C(O8)C)O)O)O)C)C)O)C)OC1

InChI=1S/C39H62O13/c1-18-8-13-38(47-17-18)20(3)39(46)27(52-38)15-25-23-7-6-21-14-22(9-11-36(21,4)24(23)10-12-37(25,39)5)49-35-33(31(44)29(42)26(16-40)50-35)51-34-32(45)30(43)28(41)19(2)48-34/h6,18-20,22-35,40-46H,7-17H2,1-5H3/t18-,19+,20-,22+,23-,24+,25+,26-,27+,28+,29-,30-,31+,32-,33-,34-,35-,36+,37+,38-,39-/m1/s1

WHWWQGPCTUQCMN-JDDKMXSSSA-N

>98%

White crystal

Anticytotoxic

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