Description
Glycitin is an isoflavonoid recently found in flowers of Pueraria thunbergianaI. It can be modified into the metabolite glycitein which has anti-inflammatory properties. It promotes the proliferation of bone marrow stromal cells and osteoblasts and suppresses bone turnover. It is effective in preventing bone loss and reversing the unfavorable changes of lipid metabolism. It may modulate differentiation of MSC to cause a lineage shift toward the osteoblast and away from the adipocytes, and could inhibit adipocytic transdifferen-tiation of osteoblasts. It could also be helpful in preventing the development of osteonecrosis.
Synonyms
7-(b-D-Glucopyranosyloxy)-3-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one; Glycitein-7-O-b-D-glucoside
IUPAC Name
3-(4-hydroxyphenyl)-6-methoxy-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one
Molecular Formula
C22H22O10
Canonical SMILES
COC1=C(C=C2C(=C1)C(=O)C(=CO2)C3=CC=C(C=C3)O)OC4C(C(C(C(O4)CO)O)O)O
InChI
InChI=1S/C22H22O10/c1-29-15-6-12-14(30-9-13(18(12)25)10-2-4-11(24)5-3-10)7-16(15)31-22-21(28)20(27)19(26)17(8-23)32-22/h2-7,9,17,19-24,26-28H,8H2,1H3/t17-,19-,20+,21-,22-/m1/s1
InChIKey
OZBAVEKZGSOMOJ-MIUGBVLSSA-N
Boiling Point
751.1±60.0 °C at 760 mmHg
Flash Point
264.1±26.4 °C
Solubility
Soluble in DMSO
Application
A metabolite of isoflavone derivatives.
Shelf Life
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Vapor Pressure
0.0±2.6 mmHg at 25°C