Description
Wilforlide A is extracted from the herb of Tripterygium wilfordii Hook.f. It has obvious anti-inflammatory effect at high-dose.
Synonyms
Regelide; Abruslactone A; (3β,22α)-3-Hydroxy-22,29-epoxyolean-12-en-29-one; Wilforlide; Olean-12-en-29-oic acid, 3,22-dihydroxy-, γ-lactone, (3β,20α,22α)-; 3-epiabruslactone A
IUPAC Name
(1S,2R,5S,6R,9R,11S,14R,15R,19S,21S)-11-hydroxy-2,5,6,10,10,14,21-heptamethyl-23-oxahexacyclo[19.2.1.02,19.05,18.06,15.09,14]tetracos-17-en-22-one
Molecular Formula
C30H46O3
Canonical SMILES
CC1(C2CCC3(C(C2(CCC1O)C)CC=C4C3(CCC5(C4CC6(CC5OC6=O)C)C)C)C)C
InChI
InChI=1S/C30H46O3/c1-25(2)20-10-13-30(7)21(28(20,5)12-11-22(25)31)9-8-18-19-16-26(3)17-23(33-24(26)32)27(19,4)14-15-29(18,30)6/h8,19-23,31H,9-17H2,1-7H3/t19-,20-,21+,22-,23-,26-,27+,28-,29+,30+/m0/s1
InChIKey
HHQJBWYXBWOFJY-YLXTXNMFSA-N
Boiling Point
555.0±50.0 °C | Condition: Press: 760 Torr
Density
1.12±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
Solubility
Soluble in DMSO, Methanol
Application
Wilforlide A has obvious anti-inflammatory effect at high-dose, but has no significant immune suppressive activity.
Shelf Life
2 month in rt, long time
pKa
15.17±0.70(Predicted)
Uses
Wilforlide A is a terpenoid found in tissue cultures of tripterygium wilfordii.