VERATRIDINE

Inquiry

For Research Use Only.

Category

Alkaloids

Cat.No.

NP0063

CAS

71-62-5

Product Name

VERATRIDINE

Structure

Product Details

Description

Veratridine, a pentacyclic triterpene acid compound, has been found to be a steroid-derived alkaloid neurotoxin and could be used as a voltage-gated Na+ channel opener.

Synonyms

Veratrin (Amorphous); (3β,4α,16β)-4,12,14,16,17,20-Hexahydroxy-4,9-epoxycevan-3-yl 3,4-dimethoxybenzoate

IUPAC Name

[(1R,2S,6S,9S,10R,11S,12S,14R,15S,18S,19S,22S,23S,25R)-1,10,11,12,14,23-hexahydroxy-6,10,19-trimethyl-24-oxa-4-azaheptacyclo[12.12.0.02,11.04,9.015,25.018,23.019,25]hexacosan-22-yl] 3,4-dimethoxybenzoate

Molecular Weight

673.79

Molecular Formula

C36H51NO11

Canonical SMILES

CC1CCC2C(C3(C(CC4(C5CCC6C7(C5(CC4(C3CN2C1)O)OC6(C(CC7)OC(=O)C8=CC(=C(C=C8)OC)OC)O)C)O)O)O)(C)O

InChI

InChI=1S/C36H51NO11/c1-19-6-11-26-31(3,40)35(43)25(17-37(26)16-19)33(42)18-34-24(32(33,41)15-27(35)38)10-9-23-30(34,2)13-12-28(36(23,44)48-34)47-29(39)20-7-8-21(45-4)22(14-20)46-5/h7-8,14,19,23-28,38,40-44H,6,9-13,15-18H2,1-5H3/t19-,23-,24-,25-,26-,27-,28-,30-,31+,32+,33+,34+,35-,36-/m0/s1

InChIKey

FVECELJHCSPHKY-YFUMOZOISA-N

Boiling Point

814.5°C at 760 mmHg

Melting Point

180°C

Purity

≥90% by HPLC

Density

1.45 g/cm3

Solubility

Soluble in ethanol (50 mg/mL)

Appearance

White Powder

Storage

Store at -20°C (dark)

Alpha

D20 +8.0° (ethanol)

BRN

78875

Color

White to Off-White

EINECS

200-758-4

Form

Solid

Hazard Class

6.1(a)

Hazard Codes

T+

Merck

13,10016

Packing Groups

pKa

9.54(at 25°C)

Refractive Index

1.6630 (estimate)

RIDADR

UN 1544 6.1/PG 1

Risk Statements

26/27/28-36/37/38-62-52/53-48/20

RTECS

YX5600000

Safety Statements

26-36/37/39-45-61-36/37-28

Toxicity

LD50 in mice (mg/kg): 1.35 i.p. (Swiss, Bauer); 0.42 i.v. (Krayer); 6.3 s.c. (Tanaka)

Uses

Veratridine causes Na+ channels to stay open during a sustained membrane depolarization by abolishing inactivation.

WGK Germany

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