Ursodeoxycholic Acid

For Research Use Only.
Category
Steroids
Cat.No.
NP6089
CAS
128-13-2
Product Name
Ursodeoxycholic Acid
Structure

Product Details

Description
Ursodeoxycholic acid (UDCS) is a cell protectant used extensively to mitigate hepatic and biliary diseases. Ursodeoxycholic acid may be used to study its specific activities that range from reduction of cholesterol absorpition, cholesterol gallstone dissolution to suppression of immune response.IC50: M1-family aminopeptidase: IC50 = 2.6 µM (Plasmodium falciparum 3D7); NTCP: IC50 = 3.6 µM (human); HCT-116: IC50 = >50 µM (human); GBM: IC50 = >50 µM (human) Asbt: Ki= 75 µM (human)
Synonyms
5beta-cholanic acid-3alpha,7beta-diol; Actigall; ursodeoxycholate; ursodiol; Ursodeoxycholic acid
IUPAC Name
(4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
Molecular Weight
392.57
Molecular Formula
C24H40O4
Canonical SMILES
CC(CCC(=O)O)C1CCC2C1(CCC3C2C(CC4C3(CCC(C4)O)C)O)C
InChI
1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16-,17-,18+,19+,20+,22+,23+,24-/m1/s1
InChIKey
RUDATBOHQWOJDD-UZVSRGJWSA-N
Boiling Point
547.1°C
Melting Point
203-204 °C (lit.)
Flash Point
298.8°C
Purity
≥ 99.0%
Density
1.128 g/cm3
Solubility
Soluble in Ethanol (50 mg/ml)
Appearance
White Crystal Powder
Application
Gallstone-dissolving drugs; Anti-neoplastic; For the prevention and treatment of cholesterol gallstones; Reduces hydrophobic bile acids and decreases both lymphocyte reactivity and serum alkaline phosphatase levels,IC50: M1-family aminopeptidase: IC50 = 2.6 µM (Plasmodium falciparum 3D7); NTCP: IC50 = 3.6 µM (human); HCT-116: IC50 = >50 µM (human); GBM: IC50 = >50 µM (human) Asbt: Ki= 75 µM (human)
Shelf Life
1 Year
Storage
Store at RT
EINECS
204-879-3
Form
Powder
Hazard Codes
Xi
HS Code
2918199090
MDL
MFCD00003680
Packaging
100 g / 1 kg
Risk Statements
R36/37/38
RTECS
FZ2000000
Safety Statements
S24/25
Stability
Stable under normal temperatures and pressures.
WGK Germany
2
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