(+)-TUBOCURARINE CHLORIDE PENTAHYDRATE

Inquiry

For Research Use Only.

Category

Alkaloids

Cat.No.

NP0033

CAS

6989-98-6

Product Name

(+)-TUBOCURARINE CHLORIDE PENTAHYDRATE

Structure

Product Details

Description

Tubocurarine is a toxic alkaloid. It is an acetylcholine receptor (AChR)-blocking agent. Tubocurarine is now rarely used as an adjunct for clinical anesthesia because safer alternatives like cisatracurium and rocuronium.

Synonyms

UNII-900961Z8VR; D-Tubocurarine chloride pentahydrate; (+)-Tubocurarine chloride pentahydrate; (+)-Tubocurarine chloride hydrochloride pentahydrate

IUPAC Name

(1S,16R)-10,25-dimethoxy-15,15,30-trimethyl-7,23-dioxa-30-aza-15-azoniaheptacyclo[22.6.2.23,6.18,12.118,22.027,31.016,34]hexatriaconta-3(36),4,6(35),8(34),9,11,18(33),19,21,24,26,31-dodecaene-9,21-diol;chloride;pentahydrate;hydrochloride

Molecular Weight

771.72

Molecular Formula

C37H41ClN2O6·HCl·5H2O

Canonical SMILES

CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C6C(CC7=CC(=C(C=C7)O)O3)[N+](CCC6=CC(=C5O)OC)(C)C)OC.O.O.O.O.O.Cl.[Cl-]

InChI

InChI=1S/C37H40N2O6.2ClH.5H2O/c1-38-14-12-24-19-32(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-37-35-25(20-34(43-5)36(37)41)13-15-39(2,3)29(35)17-23-8-11-30(40)31(18-23)45-33;;;;;;;/h6-11,18-21,28-29H,12-17H2,1-5H3,(H-,40,41);2*1H;5*1H2/t28-,29+;;;;;;;/m0......./s1

InChIKey

WMIZITXEJNQAQK-GGDSLZADSA-N

Melting Point

275-280 °C (dec.)(lit.)

Purity

97%

Density

1.2074 g/cm3(rough estimate)

Solubility

H2O: soluble50 mg/ml, with heating as required, clear to slightly hazy, colorless to yellow

Appearance

Powder

Application

clinical anesthesia

Shelf Life

2 month in rt, long time

Storage

-20°C Freezer

BRN

3896374

Color

Light Brown

EINECS

615-023-7

10-23

Form

Solid

Hazard Class

6.1

Hazard Codes

HS Code

29349990

Merck

14,9807

Packing Groups

III

Refractive Index

193 ° (C=1, H2O)

RIDADR

UN 1544 6.1/PG 3

Risk Statements

RTECS

YO5100000

Safety Statements

45-36/37/39-22

Uses

Tubocurarine is used mainly in anesthesiology as a myorelaxant, causing prolonged muscle relaxation during an operation. Small doses are successful at causing temporary relaxation of skeletal muscle without any vital change of primary body functions.

Water Solubility

Soluble in water to 50 mg/mL

WGK Germany

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