Triptophenolide

Inquiry
For Research Use Only.
Category
Diterpenoids
Cat.No.
NP1537
CAS
74285-86-2
Product Name
Triptophenolide
Structure
Structure

Product Details

Description
Triptophenolide is a natural product derived from the traditional Chinese medicinal plant Tripterygium wilfordii. It is a diterpenoid compound known for its diverse biological activities, including anti-inflammatory, immunosuppressive, and anticancer properties.
Synonyms
Tryptophenolide; Hypolide; Phenanthro(1,2-c)furan-1(3H)-one, 3b,4,5,9b,10,11-hexahydro-6-hydroxy-9b-methyl-7-(1-methylethyl)-, (3bR-trans)-; (+)-Triptophenolide; (3bR,9bS)-6-Hydroxy-7-isopropyl-9b-methyl-3b,4,5,9b,10,11-hexahydrophenanthro[1,2-c]furan-1(3H)-one; (3bR,9bS)-3b,4,5,9b,10,11-Hexahydro-6-hydroxy-9b-methyl-7-(1-methylethyl)phenanthro[1,2-c]furan-1(3H)-one
IUPAC Name
(3bR,9bS)-6-hydroxy-9b-methyl-7-propan-2-yl-3,3b,4,5,10,11-hexahydronaphtho[2,1-e][2]benzofuran-1-one
Molecular Weight
312.40
Molecular Formula
C20H24O3
Canonical SMILES
CC(C)C1=C(C2=C(C=C1)[C@]3(CCC4=C([C@@H]3CC2)COC4=O)C)O
InChI
InChI=1S/C20H24O3/c1-11(2)12-4-6-16-14(18(12)21)5-7-17-15-10-23-19(22)13(15)8-9-20(16,17)3/h4,6,11,17,21H,5,7-10H2,1-3H3/t17-,20+/m0/s1
InChIKey
KPXIBWGPZSPABK-FXAWDEMLSA-N
Boiling Point
490.0±45.0 °C | Condition: Press: 760 Torr
Melting Point
232-233 °C
Purity
>98%
Density
1.21±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
Solubility
Soluble in DMSO
Appearance
White crystalline powder
Application
triptophenolide can remarkably inhibit the delayed type hypersensitivity (DTH) reaction induced by DNCB and BSA in vitro. It also could diminishe the peripheral blood ANAE+lymphocytes in rats and micc. It can significautly increase the amount of total serum complement and dramatically decrcase the serum antibody products (1gG ) of rats and mice.
Shelf Life
2 month in rt, long time
Storage
Store at -20 °C
Color
Yellow
Form
Powder
Packaging
20 mg
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