Trimethoprim

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For Research Use Only.

Category

Impurities

Cat.No.

NP3121

CAS

738-70-5

Product Name

Trimethoprim

Structure

Product Details

Description

Trimethoprim is a bacteriostatic antibiotic used mainly in the prophylaxis and treatment of urinary tract infections. It caused induction of DnaK, DnaJ, GroEL, ClpB, and IbpA/B Hsps. It binds to dihydrofolate reductase and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF).

Synonyms

Trimpex; Proloprim

IUPAC Name

5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine

Molecular Weight

290.32

Molecular Formula

C14H18N4O3

Canonical SMILES

COC1=CC(=CC(=C1OC)OC)CC2=CN=C(N=C2N)N

InChI

InChI=1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)

InChIKey

IEDVJHCEMCRBQM-UHFFFAOYSA-N

Boiling Point

526°C at 760 mmHg

Melting Point

199-203°C

Flash Point

271.9°C

Purity

>98%

Density

1.252 g/cm3

Solubility

Soluble in DMSO

Appearance

White to Light Yellow Solid

Application

Anti-infective agents, Urinary; antimalarials; antimetabolites; folic acid antagonists

Storage

Store at 2-8°C

Form

Powder

Hazard Class

6.1(b)

Hazard Codes

HS Code

2933599090

RIDADR

UN 3249

Risk Statements

R25

RTECS

UV8225000

Safety Statements

S45

Stability

Stable. Incompatible with strong oxidizing agents, acids.

Vapor Pressure

0.0±0.9 mmHg at 25°C

WGK Germany

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