Trigonelline hydrochloride

Inquiry

For Research Use Only.

Category

Alkaloids

Cat.No.

NP0032

CAS

6138-41-6

Product Name

Trigonelline hydrochloride

Structure

Product Details

Description

Trigonelline has hypoglycemic, hypolipidemic, neuroprotective, antimigraine, sedative, memory-improving, antibacterial, antiviral, and anti-tumor activities, and it has been shown to reduce diabetic auditory neuropathy and platelet aggregation. It acts by affecting β cell regeneration, insulin secretion, activities of enzymes related to glucose metabolism, reactive oxygen species, axonal extension, and neuron excitability.

Synonyms

1-METHYLPYRIDINIUM-3-CARBOXYLATE HYDROCHLORIDE; N-METHYLNICOTINIC ACID BETAINE HYDROCHLORIDE; TRIGONELLIN HYDROCHLORIDE; TRIGONELLINE HYDROCHLORIDE; TRIGONELLINE HCL; TIMTEC-BB SBB000182; 3-carboxy-1-methylpyridinium chloride; Trigonelline chloride

IUPAC Name

1-methylpyridin-1-ium-3-carboxylic acid;chloride

Molecular Weight

173.6

Molecular Formula

C7H8ClNO2

Canonical SMILES

[Cl-].C[n+]1cccc(c1)C(O)=O

InChI

InChI=1S/C7H7NO2.ClH/c1-8-4-2-3-6(5-8)7(9)10;/h2-5H,1H3;1H

InChIKey

TZSYLWAXZMNUJB-UHFFFAOYSA-N

Melting Point

~260 °C (dec.)

Purity

>98%

Solubility

In Vitro:
DMSO : 6 mg/mL (34.56 mM; Need ultrasonic)

Appearance

Powder

Application

hypoglycemic, hypolipidemic, neuroprotective, antimigraine, sedative, memory-improving, antibacterial, antiviral, and anti-tumor

Storage

4°C, sealed storage, away from moisture
* In solvent :
-80°C, 6 months
-20°C, 1 month (sealed storage, away from moisture)

BRN

3734169

Color

Orange to Dark Orange

EINECS

228-119-5

Form

Solid

Hazard Codes

HS Code

29333990

MDL

MFCD00077250

Merck

14,9694

NACRES

NA.24

Risk Statements

36/37/38

Safety Statements

22-24/25-36-26

Uses

Trigonelline (chloride) is an alkaloid found in plants and coffee. Trigonelline is a product of niacin metabolism that is excreted in urine.

Water Solubility

Soluble

WGK Germany

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