Trigonelline hydrochloride

For Research Use Only.
Category
Alkaloids
Cat.No.
NP0032
CAS
6138-41-6
Product Name
Trigonelline hydrochloride
Structure

Product Details

Description
Trigonelline has hypoglycemic, hypolipidemic, neuroprotective, antimigraine, sedative, memory-improving, antibacterial, antiviral, and anti-tumor activities, and it has been shown to reduce diabetic auditory neuropathy and platelet aggregation. It acts by affecting β cell regeneration, insulin secretion, activities of enzymes related to glucose metabolism, reactive oxygen species, axonal extension, and neuron excitability.
Synonyms
1-METHYLPYRIDINIUM-3-CARBOXYLATE HYDROCHLORIDE; N-METHYLNICOTINIC ACID BETAINE HYDROCHLORIDE; TRIGONELLIN HYDROCHLORIDE; TRIGONELLINE HYDROCHLORIDE; TRIGONELLINE HCL; TIMTEC-BB SBB000182; 3-carboxy-1-methylpyridinium chloride; Trigonelline chloride
IUPAC Name
1-methylpyridin-1-ium-3-carboxylic acid;chloride
Molecular Weight
173.6
Molecular Formula
C7H8ClNO2
Canonical SMILES
[Cl-].C[n+]1cccc(c1)C(O)=O
InChI
InChI=1S/C7H7NO2.ClH/c1-8-4-2-3-6(5-8)7(9)10;/h2-5H,1H3;1H
InChIKey
TZSYLWAXZMNUJB-UHFFFAOYSA-N
Melting Point
~260 °C (dec.)
Purity
>98%
Solubility
In Vitro:
DMSO : 6 mg/mL (34.56 mM; Need ultrasonic)
Appearance
Powder
Application
hypoglycemic, hypolipidemic, neuroprotective, antimigraine, sedative, memory-improving, antibacterial, antiviral, and anti-tumor
Storage
4°C, sealed storage, away from moisture
* In solvent :
-80°C, 6 months
-20°C, 1 month (sealed storage, away from moisture)
BRN
3734169
Color
Orange to Dark Orange
EINECS
228-119-5
Form
Solid
Hazard Codes
Xi
HS Code
29333990
MDL
MFCD00077250
Merck
14,9694
NACRES
NA.24
Risk Statements
36/37/38
Safety Statements
22-24/25-36-26
Uses
Trigonelline (chloride) is an alkaloid found in plants and coffee. Trigonelline is a product of niacin metabolism that is excreted in urine.
Water Solubility
Soluble
WGK Germany
3
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