Toddaculin

Coumarins

NP1046

4335-12-0

Toddaculin

Toddaculin may be beneficial for the prevention and treatment of osteoporosis, it can not only inhibit the differentiation of osteoclasts via activation of the NF-B, ERK 1/2, and p38 MAPK signaling pathways, but can induce differentiation and mineralization of osteoblasts by regulating differentiation factors. Toddaculin is also a natural coumarin that can induce differentiation and apoptosis in leukemic cells.

Toddaculine; 2H-1-Benzopyran-2-one, 5,7-dimethoxy-6-(3-methyl-2-butenyl)-; 6-(3-Methyl-2-butenyl)-5,7-dimethoxy-2H-1-benzopyran-2-one

5,7-dimethoxy-6-(3-methylbut-2-enyl)chromen-2-one

274.31

C16H18O4

CC(=CCC1=C(C=C2C(=C1OC)C=CC(=O)O2)OC)C

InChI=1S/C16H18O4/c1-10(2)5-6-11-13(18-3)9-14-12(16(11)19-4)7-8-15(17)20-14/h5,7-9H,6H2,1-4H3

KRQHZFHWEAJPNO-UHFFFAOYSA-N

98.0%

Oil