TMC-58B

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For Research Use Only.

Size	Price	Stock	Quantity
1 mg	$469	In stock

Category

Alkaloids

Cat.No.

NP0417

CAS

58115-31-4

Product Name

TMC-58B

Structure

Product Details

Description

Aurantiamide, a natural alkaloid found in the herbs of Walsura yunnanensis, is used as significant anti-inflammatory and antinociceptive. it can serve as the natural compound for inhibiting cysteine proteinases, in particular, cathepsin L (3.4.22.15) and B (3.4.22.1) with IC50 of 12 microM and 49 microM, respectively. It may suppress the growth of malignant gliomas by blocking autophagic flux.

Synonyms

(S)-α-(Benzoylamino)-N-[(S)-1-(hydroxymethyl)-2-phenylethyl]benzenepropanamide

IUPAC Name

N-[(2S)-1-[[(2S)-1-hydroxy-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]benzamide

Molecular Weight

402.5

Molecular Formula

C25H26N2O3

Canonical SMILES

C1=CC=C(C=C1)CC(CO)NC(=O)C(CC2=CC=CC=C2)NC(=O)C3=CC=CC=C3

InChI

InChI=1S/C25H26N2O3/c28-18-22(16-19-10-4-1-5-11-19)26-25(30)23(17-20-12-6-2-7-13-20)27-24(29)21-14-8-3-9-15-21/h1-15,22-23,28H,16-18H2,(H,26,30)(H,27,29)/t22-,23-/m0/s1

InChIKey

KSVKECXWDNCRTM-GOTSBHOMSA-N

Boiling Point

723.6±60.0°C (Predicted)

Purity

>95%

Density

1.191±0.06 g/cm3(Predicted)

Appearance

Powder

Application

anti-neuroinflammatory; anti-inflammatory; antinociceptive

Form

Powder

pKa

13.31±0.46(Predicted)

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