Thalidezine

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For Research Use Only.

Category

Alkaloids

Cat.No.

NP0848

CAS

18251-36-0

Product Name

Thalidezine

Structure

Product Details

Description

Thalidezine is an alkaloid isolated from the roots of Thalictrum podocarpum Humb. Biolayer interferometry analysis and AMPK kinase assays indicated that thalidezine is a novel AMPK activator. It eliminates apoptosis-resistant cancer cells and induces autophagic cell death in apoptosis-resistant cancer via AMPK signaling.

Molecular Weight

638.761

Molecular Formula

C38H42N2O7

Canonical SMILES

CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(CCN6C)C(=C(C(=C7O3)OC)OC)O)OC)OC

InChI

InChI=1S/C38H42N2O7/c1-39-15-13-24-20-31(43-4)33-21-27(24)28(39)17-22-7-10-25(11-8-22)46-32-19-23(9-12-30(32)42-3)18-29-34-26(14-16-40(29)2)35(41)37(44-5)38(45-6)36(34)47-33/h7-12,19-21,28-29,41H,13-18H2,1-6H3

InChIKey

UYNHKOIUEXICNQ-UHFFFAOYSA-N

Purity

97.5%

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