Tetracycline

Impurities

NP3720

60-54-8

Tetracycline

Tetracycline is an antibiotic produced by various Streptomyces such as Str. viridifaciens BL-567201 and Str. aureofacies NRRL 2209. It has antibacterial and mycobacterial activity, and has cross-resistance with oxytetracycline and chlortetracycline. Human serum does not affect its antibacterial activity. It has the effect of inhibiting large viruses and the main gram. It is widely used in clinics to treat chlamydia, rickettsia, mycoplasma and bacterial infections.

Oxytetracycline EP Impurity B; (4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide; Abramycin; Achromycin; (-)-Tetracycline; 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S,4aS,5aS,6S,12aS)-; 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, [4S-(4α,4aα,5aα,6β,12aα)]-; NSC 108579; Dispatetrin; Economycin; Biocycline; Cytome; Limecycline; Medocycline; Veracin; Oxytetracycline Dihydrate EP Impurity B; Oxytetracycline Hydrochloride EP Impurity B

(4S,4aS,5aS,6S,12aR)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide

444.43

C22H24N2O8

O=C(N)C=1C(=O)C2(O)C(O)=C3C(=O)C=4C(O)=CC=CC4C(O)(C)C3CC2C(C1O)N(C)C

InChI=1S/C22H24N2O8/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30)/t9-,10-,15-,21+,22-/m0/s1

OFVLGDICTFRJMM-WESIUVDSSA-N

790.6±60.0°C at 760 mmHg

170-173°C(dec.)

>98% by HPLC

1.64±0.1 g/cm3

Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

Yellow Crystal

Antibiotics, Tetracycline; protein synthesis inhibitors

Store at -20°C

LD50 = 808mg/kg (oral, mice).