Syrosingopine

For Research Use Only.
Category
Alkaloids
Cat.No.
NP0043
CAS
84-36-6
Product Name
Syrosingopine
Structure

Product Details

Description
Syrosingopine is a dual MCT1 and MCT4 inhibitor. Syrosingopine sensitizes cancer cells to metformin, which can be a promising therapeutic strategy for clinical application for the treatment of cancer.
Synonyms
Syringopine; Menatensina; Neoreserpan
IUPAC Name
methyl (1S,2R,3R,4aS,13bR,14aS)-3-((4-((ethoxycarbonyl)oxy)-3,5-dimethoxybenzoyl)oxy)-2,11-dimethoxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroindolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylate
Molecular Weight
666.72
Molecular Formula
C35H42N2O11
Canonical SMILES
O=C(OC1=C(OC)C=C(C=C1OC)C(=O)OC2CC3CN4CCC=5C=6C=CC(OC)=CC6NC5C4CC3C(C(=O)OC)C2OC)OCC
InChI
InChI=1S/C35H42N2O11/c1-7-46-35(40)48-31-26(42-3)12-18(13-27(31)43-4)33(38)47-28-14-19-17-37-11-10-22-21-9-8-20(41-2)15-24(21)36-30(22)25(37)16-23(19)29(32(28)44-5)34(39)45-6/h8-9,12-13,15,19,23,25,28-29,32,36H,7,10-11,14,16-17H2,1-6H3
InChIKey
ZCDNRPPFBQDQHR-UHFFFAOYSA-N
Boiling Point
795°C at 760 mmHg
Melting Point
175°C
Density
1.35 g/cm3
Solubility
Chloroform (Slightly), Methanol (Slightly)
Storage
Hygroscopic, -20°C Freezer, Under inert atmosphere
Color
White to faint yellow
Definition
Methyl reserpate
ester of syringic acid ethyl carbonate. An analog
of reserpine.
EINECS
201-527-0
Form
Powder
Hazard Class
6.1(b)
NACRES
NA.77
Packing Groups
III
pKa
18.11±0.70(Predicted)
Refractive Index
1.5300 (estimate)
RIDADR
1544
Toxicity
LD50 oral in rat: > 2gm/kg
Uses
Syrosingopine is a pharmaceutical used to treat hypertension.
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