Swainsonine

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For Research Use Only.

Category

Alkaloids

Cat.No.

NP0068

CAS

72741-87-8

Product Name

Swainsonine

Structure

Product Details

Description

Swainsonine is a plant alkaloid derived from Swainsona canescens (a leguminous plant). It is a reversible, active-site directed inhibitor of α-mannosidase at concentrations of 5-10 mM.

Synonyms

Tridolgosir; 8α,β-Octahydroindolizidine-1α,2α,8β-triol; (-)-Swainsonine; (1S,2R,8R,8aR)-Octahydroindolizidinetriol; 1,2,8-Indolizinetriol, octahydro-, (1S-(1alpha,2alpha,8beta,8abeta))-

IUPAC Name

(1S,2R,8R,8aR)-1,2,3,5,6,7,8,8a-octahydroindolizine-1,2,8-triol

Molecular Weight

173.21

Molecular Formula

C8H15NO3

Canonical SMILES

C1CC(C2C(C(CN2C1)O)O)O

InChI

InChI=1S/C8H15NO3/c10-5-2-1-3-9-4-6(11)8(12)7(5)9/h5-8,10-12H,1-4H2/t5-,6-,7-,8-/m1/s1

InChIKey

FXUAIOOAOAVCGD-WCTZXXKLSA-N

Boiling Point

353.3±21.0°C (Predicted)

Melting Point

>125°C (dec.)

Purity

≥98%

Density

1.38±0.1 g/cm3 at 20°C 760 Torr

Solubility

Soluble in DMSO (Slightly), Methanol (Slightly)

Appearance

White to Off-white Solid

Storage

Store at -20°C

BRN

4175740

Color

White to Off-White

Definition

ChEBI: An indolizidine alkaloid isolated from the plant Swainsona canescens with three hydroxy substituents at positions 1, 2 and 8.

Form

Solid

Hazard Codes

HS Code

29339900

pKa

14.01±0.60(Predicted)

Risk Statements

20/21/22

RTECS

NM2408666

Safety Statements

Stability

Stable for 1 year from date of purchase as supplied. Solutions in DMSO, ethanol or distilled water may be stored at -20°C for up to 3 months.

Uses

Swainsonine is a plant alkaloid derived from Swainsona canescens (a leguminous plant). It is a reversible, active-site directed inhibitor of a-mannosidase at concentrations of 5-10mM.

Water Solubility

H2O: 1 mg/mL

WGK Germany

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