Sophocarpine

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For Research Use Only.

Size	Price	Stock	Quantity
50 mg	$159	In stock

Category

Alkaloids

Cat.No.

NP0061

CAS

6483-15-4

Product Name

Sophocarpine

Structure

Product Details

Description

Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects. Sophocarpine significantly inhibits the growth of gastric cancer (GC) cells through multiple mechanisms such as induction of autophagy, activation of cell apoptosis and down-regulation of cell survival PI3K/AKT signaling pathway.

Synonyms

AS 604850; AS604850; AS-604850; 13,14-Didehydromatridin-15-one; (7aS,13aR,13bR,13cS)-2,3,6,7,7a,8,13,13a,13b,13c-decahydro-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one

IUPAC Name

(1R,2R,9S,17S)-7,13-diazatetracyclo[7.7.1.02,7.013,17]heptadec-4-en-6-one

Molecular Weight

246.35

Molecular Formula

C15H22N2O

Canonical SMILES

C1CC2CN3C(CC=CC3=O)C4C2N(C1)CCC4

InChI

InChI=1S/C15H22N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h1,7,11-13,15H,2-6,8-10H2/t11-,12+,13+,15-/m0/s1

InChIKey

AAGFPTSOPGCENQ-JLNYLFASSA-N

Boiling Point

425.4±45.0 °C at 760 mmHg

Melting Point

54~55°C

Flash Point

194.0±21.1 °C

Purity

>98%

Density

1.2±0.1 g/cm3

Solubility

In vitro:
10 mM in DMSO

Appearance

Powder

Application

anti-tumor; anti-cancer; antiarrhythmic;

Storage

Powder:
-20°C: 3 years
4°C: 2 years
In solvent:
-80°C: 6 months
-20°C: 1 month

Color

Light Orange to Brown

Form

Solid

MDL

MFCD00274555

Packaging

50 mg

pKa

9.59±0.20(Predicted)

Uses

Sophocarpine is an intermediate in the synthesis of (+)-Matrine-d3 (M197872). (+)-Matrine-d3, is a labeled analogue of (+)-Matrine, an alkaloid compound extracted from the roots of Sophora species which maintain anti-inflammatory, anti-cancer and a host of other positive pharmacological effects.

Vapor Pressure

0.0±1.0 mmHg at 25°C

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