Solamargine

Inquiry

For Research Use Only.

Size	Price	Stock	Quantity
25 mg	$298	In stock

Category

Alkaloids

Cat.No.

NP0028

CAS

20311-51-7

Product Name

Solamargine

Structure

Product Details

Description

Solamargine, a steroidal alkaloid glycoside, is isolated from the fruits of a traditional Chinese medicinal herb called Solanum incanum L., triggered gene expression of human tumor necrosis factor receptor (TNFR) I which might lead to cell apoptosis.

Synonyms

Solasodine-L-rhamnosido-D-glucoside; β-D-Glucopyranoside, (3β,22α,25R)-spirosol-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[6-deoxy-α-L-mannopyranosyl-(1→4)]-; (3β,22α,25R)-Spirosol-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[6-deoxy-α-L-mannopyranosyl-(1→4)]-β-D-glucopyranoside; NSC 407810; Solamargin; α-Solamargine; δ-Solanigrine

IUPAC Name

(2S,3R,4R,5R,6S)-2-[(2R,3S,4S,5R,6R)-4-hydroxy-2-(hydroxymethyl)-6-[(1S,2S,4S,5'R,6R,7S,8R,9S,12S,13R,16S)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-piperidine]-16-yl]oxy-5-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl]oxy-6-methyloxane-3,4,5-triol

Molecular Weight

868.06

Molecular Formula

C45H73NO15

Canonical SMILES

CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CC=C6C5(CCC(C6)OC7C(C(C(C(O7)CO)OC8C(C(C(C(O8)C)O)O)O)O)OC9C(C(C(C(O9)C)O)O)O)C)C)C)NC1

InChI

InChI=1S/C45H73NO15/c1-19-9-14-45(46-17-19)20(2)30-28(61-45)16-27-25-8-7-23-15-24(10-12-43(23,5)26(25)11-13-44(27,30)6)57-42-39(60-41-36(53)34(51)32(49)22(4)56-41)37(54)38(29(18-47)58-42)59-40-35(52)33(50)31(48)21(3)55-40/h7,19-22,24-42,46-54H,8-18H2,1-6H3/t19-,20+,21+,22+,24+,25-,26+,27+,28+,29-,30+,31+,32+,33-,34-,35-,36-,37+,38-,39-,40+,41+,42-,43+,44+,45-/m1/s1

InChIKey

MBWUSSKCCUMJHO-ZGXDEBHDSA-N

Melting Point

301°C

Purity

>98%

Density

1.38±0.1 g/cm3

Solubility

Soluble in DMSO

Appearance

White powder

Application

anti-trypanosomal

Shelf Life

2 years

Storage

Store in a cool and dry place and at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)

Color

White to Off-White

Form

Solid

Packaging

25 mg

Uses

α-Solamargine is a steroidal glycosyl-alkaloid which displays inactivation of PI3-L/Akt and reduction for SP1 and p65 in the suppression of human lung cancer cells.

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