Seneciphylline

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For Research Use Only.

Size	Price	Stock	Quantity
10 mg	$469	In stock

Category

Alkaloids

Cat.No.

NP0002

CAS

480-81-9

Product Name

Seneciphylline

Structure

Product Details

Description

Seneciphylline, a natural pyrrolizidine alkaloid isolated from the herbs of Senecio scandens, may cause reduction of cytochrome P-450 and related monooxygenase activities. Seneciphylline is a pyrrolizidine alkaloid with the potential to affect hepatic drug metabolizing enzymes in rat cells. In vitro, seneciphylline has no effection on hepatic drug metabolizing enzymes, but has seneciphyllineslight activity of reducing aminopyrine demethylase.

Synonyms

Jacodine; (15cis)-12-Hydroxy-13,19-didehydrosenecionan-11,16-dione; 13,19-didehydro-12-hydroxysenecionan-11,16-dione

IUPAC Name

(1R,4Z,7R,17R)-4-ethylidene-7-hydroxy-7-methyl-6-methylidene-2,9-dioxa-14-azatricyclo[9.5.1.014,17]heptadec-11-ene-3,8-dione

Molecular Weight

333.4

Molecular Formula

C18H23NO5

Canonical SMILES

CC=C1CC(=C)C(C(=O)OCC2=CCN3C2C(CC3)OC1=O)(C)O

InChI

InChI=1S/C18H23NO5/c1-4-12-9-11(2)18(3,22)17(21)23-10-13-5-7-19-8-6-14(15(13)19)24-16(12)20/h4-5,14-15,22H,2,6-10H2,1,3H3/b12-4-/t14-,15-,18-/m1/s1

InChIKey

FCEVNJIUIMLVML-QPSVUOIXSA-N

Boiling Point

470.34°C (rough estimate)

Melting Point

217°C

Purity

>98%

Density

1.27g/cm3

Solubility

less than 0.1 mg/mL at 64 °F

Appearance

Powder

Storage

-20°C

Alpha

D -128° (chloroform)

Form

Neat

Hazard Class

6.1(b)

Hazard Codes

Packaging

10 mg

Packing Groups

III

pKa

12.43±0.20(Predicted)

Refractive Index

1.5740 (estimate)

RIDADR

1544

Risk Statements

23/24/25-25

Safety Statements

1-20-24/25-45

Stability

Stable, but reacts with oxygen in the air. Incompatible with alkali, oxidizing agents. Store under inert gas.

Uses

Seneciphylline is a minor constituent of S. jacobaea, which has been used as a medicinal herb. It has the effect of coagulation and hemostasis.Seneciphylline is a pyrrolizidine alkaloid with the potential to affect hepatic drug metabolizing enzymes in rat cells.

WGK Germany

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