Roflumilast

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For Research Use Only.

Size	Price	Stock	Quantity
250 mg	$199	In stock

Category

Impurities

Cat.No.

NP3665

CAS

162401-32-3

Product Name

Roflumilast

Structure

Product Details

Description

Roflumilast has anti-inflammatory effects and is under development as an orally administered drug for the treatment of inflammatory conditions of the lungs such as asthma, and chronic obstructive pulmonary disease (COPD). While Roflumilast was found to be effective in clinical trials, it produced several dose-limiting side effects including nausea, diarrhoea and headache, and development is continuing in an attempt to minimise the incidence of side effects while retaining clinical efficacy.

Synonyms

BY217; BY-217; BY 217; B 9302-107; B9302-107; B-9302-107; BYK 20869; BYK-20869; BYK20869; Daxas; Daliresp

IUPAC Name

3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide

Molecular Weight

403.207

Molecular Formula

C17H14Cl2F2N2O3

Canonical SMILES

C1CC1COC2=C(C=CC(=C2)C(=O)NC3=C(C=NC=C3Cl)Cl)OC(F)F

InChI

InChI=1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24)

InChIKey

MNDBXUUTURYVHR-UHFFFAOYSA-N

Boiling Point

430.6±45.0 °C at 760 mmHg

Melting Point

154-158°C

Flash Point

214.2±28.7 °C

Purity

99%

Density

1.5±0.1 g/cm3

Solubility

In vitro:
10 mM in DMSO

Appearance

White to off-White Solid

Storage

Powder:
-20°C: 3 years
4°C: 2 years
In solvent:
-80°C: 6 months
-20°C: 1 month

MDL

MFCD00938270

Packaging

250 mg

Vapor Pressure

1.28E-07mmHg at 25°C

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