Roflumilast

For Research Use Only.
Category
Impurities
Cat.No.
NP3665
CAS
162401-32-3
Product Name
Roflumilast
Structure

Product Details

Description
Roflumilast has anti-inflammatory effects and is under development as an orally administered drug for the treatment of inflammatory conditions of the lungs such as asthma, and chronic obstructive pulmonary disease (COPD). While Roflumilast was found to be effective in clinical trials, it produced several dose-limiting side effects including nausea, diarrhoea and headache, and development is continuing in an attempt to minimise the incidence of side effects while retaining clinical efficacy.
Synonyms
BY217; BY-217; BY 217; B 9302-107; B9302-107; B-9302-107; BYK 20869; BYK-20869; BYK20869; Daxas; Daliresp
IUPAC Name
3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide
Molecular Weight
403.207
Molecular Formula
C17H14Cl2F2N2O3
Canonical SMILES
C1CC1COC2=C(C=CC(=C2)C(=O)NC3=C(C=NC=C3Cl)Cl)OC(F)F
InChI
InChI=1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24)
InChIKey
MNDBXUUTURYVHR-UHFFFAOYSA-N
Boiling Point
430.6±45.0 °C at 760 mmHg
Melting Point
154-158°C
Flash Point
214.2±28.7 °C
Purity
99%
Density
1.5±0.1 g/cm3
Solubility
In vitro:
10 mM in DMSO
Appearance
White to off-White Solid
Storage
Powder:
-20°C: 3 years
4°C: 2 years
In solvent:
-80°C: 6 months
-20°C: 1 month
MDL
MFCD00938270
Packaging
250 mg
Vapor Pressure
1.28E-07mmHg at 25°C
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