Ritonavir

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For Research Use Only.

Size	Price	Stock	Quantity
1 g	$299	In stock

Category

Impurities

Cat.No.

NP2679

CAS

155213-67-5

Product Name

Ritonavir

Structure

Product Details

Description

Ritonavir is an HIV protease inhibitor. It is often used in a low dose with another protease inhibitor lopinavir. Ritonavir was approved for COVID-19 treatment in combination with Nirmatrelvir.

Synonyms

Norvir; ABT-538; A-84538; 538, ABT; ABT 538; ABT-538; ABT538; Abbott 84538

IUPAC Name

1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[[(2S)-3-methyl-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate

Molecular Weight

720.95

Molecular Formula

C37H48N6O5S2

Canonical SMILES

CC(C)C1=NC(=CS1)CN(C)C(=O)NC(C(C)C)C(=O)NC(CC2=CC=CC=C2)CC(C(CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)O

InChI

InChI=1S/C37H48N6O5S2/c1-24(2)33(42-36(46)43(5)20-29-22-49-35(40-29)25(3)4)34(45)39-28(16-26-12-8-6-9-13-26)18-32(44)31(17-27-14-10-7-11-15-27)41-37(47)48-21-30-19-38-23-50-30/h6-15,19,22-25,28,31-33,44H,16-18,20-21H2,1-5H3,(H,39,45)(H,41,47)(H,42,46)/t28-,31-,32-,33-/m0/s1

InChIKey

NCDNCNXCDXHOMX-XGKFQTDJSA-N

Boiling Point

947.0±65.0 °C at 760 mmHg

Melting Point

120-122°C

Flash Point

526.6°C

Purity

≥98%

Density

1.239 g/cm³

Solubility

In Vitro:
DMSO: 25 mg/mL (34.68 mM; Need ultrasonic)
H2O: < 0.1 mg/mL (insoluble)
In Vivo:
1.Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: 2.5 mg/mL (3.47 mM); Clear solution; Need warming 2.Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: 2.5 mg/mL (3.47 mM); Suspended solution; Need ultrasonic

Appearance

White Solid

Storage

Store at -20°C

Form

Powder

Hazard Codes

HS Code

2942000000

Packaging

1 g

Refractive Index

1.599

Risk Statements

R36/38

Safety Statements

S26; S37/39

Vapor Pressure

0.0±0.3 mmHg at 25°C

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