Rhynchophylline

For Research Use Only.
Category
Alkaloids
Cat.No.
NP0528
CAS
76-66-4
Product Name
Rhynchophylline
Structure

Product Details

Description
Rhynchophylline and isorhynchophylline act as noncompetitive antagonists of the NMDA receptor and that this property may contribute to the neuroprotective and anticonvulsant activity of the Uncaira species plant extracts.Rhynchophylline and isorhynchophylline have a non-competitive antagonistic effect on the NMDA-type ionotropic glutamate receptors, the present results suggest that these alkaloids exert their protective action against ischemia-induced neuronal damage by preventing NMDA, muscarinic M1, and 5-HT2 receptors-mediated neurotoxicity during ischemia.
Synonyms
RHYNCHOLPHYLLINE; RHYNCHOPHYLLINE; MITRINERMINE; 16e,20-alpha)-(7-bet; mitrinermin; rhynchophyllin; UNCARINE D(P); rhyncophylline
Molecular Weight
384.47
Molecular Formula
C22H28N2O4
Canonical SMILES
CCC1CN2CCC3(C2CC1C(=COC)C(=O)OC)C4=CC=CC=C4NC3=O
InChI
InChI=1S/C22H28N2O4/c1-4-14-12-24-10-9-22(17-7-5-6-8-18(17)23-21(22)26)19(24)11-15(14)16(13-27-2)20(25)28-3/h5-8,13-15,19H,4,9-12H2,1-3H3,(H,23,26)/b16-13+/t14-,15-,19-,22+/m0/s1
InChIKey
DAXYUDFNWXHGBE-KAXDATADSA-N
Boiling Point
560.8±50.0 °C | Condition: Press: 760 Torr
Melting Point
216 °C
Purity
>98%
Density
1.23±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
Solubility
10 mM in DMSO
Appearance
White cryst.
Application
Antihypertension
Shelf Life
2 month in rt, long time
Storage
-20°C Freezer
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