Rhynchophylline

Inquiry

For Research Use Only.

Category

Alkaloids

Cat.No.

NP0528

CAS

76-66-4

Product Name

Rhynchophylline

Structure

Product Details

Description

Rhynchophylline and isorhynchophylline act as noncompetitive antagonists of the NMDA receptor and that this property may contribute to the neuroprotective and anticonvulsant activity of the Uncaira species plant extracts.Rhynchophylline and isorhynchophylline have a non-competitive antagonistic effect on the NMDA-type ionotropic glutamate receptors, the present results suggest that these alkaloids exert their protective action against ischemia-induced neuronal damage by preventing NMDA, muscarinic M1, and 5-HT2 receptors-mediated neurotoxicity during ischemia.

Synonyms

RHYNCHOLPHYLLINE; RHYNCHOPHYLLINE; MITRINERMINE; 16e,20-alpha)-(7-bet; mitrinermin; rhynchophyllin; UNCARINE D(P); rhyncophylline

Molecular Weight

384.47

Molecular Formula

C22H28N2O4

Canonical SMILES

CCC1CN2CCC3(C2CC1C(=COC)C(=O)OC)C4=CC=CC=C4NC3=O

InChI

InChI=1S/C22H28N2O4/c1-4-14-12-24-10-9-22(17-7-5-6-8-18(17)23-21(22)26)19(24)11-15(14)16(13-27-2)20(25)28-3/h5-8,13-15,19H,4,9-12H2,1-3H3,(H,23,26)/b16-13+/t14-,15-,19-,22+/m0/s1

InChIKey

DAXYUDFNWXHGBE-KAXDATADSA-N

Boiling Point

560.8±50.0 °C | Condition: Press: 760 Torr

Melting Point

216 °C

Purity

>98%

Density

1.23±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr

Solubility

10 mM in DMSO