Rhoifolin

Flavonoids

NP1948

17306-46-6

Rhoifolin

Rhoifolin is a natural flavonoid isolated from the leaves of Turpinia arguya Seem. It may be beneficial for diabetic complications through their enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and GLUT4 translocation. Rhoifolin inhibits the activity of anti-inflmmatory and increases the total antioxidant capacity in a reverse dose order, which can cause a time and reverse dose dependent reduction of carrageenin-induced rat paw oedema, significantly abrogate prostaglandin E2 level, significantly diminish the TNF-a release in the inflammatory exudates. The compound could also be used as an ideal anticancer agent, and it discriminates between cancerous and non cancerous cell as it kills only the former one, so the side effects which may appear during chemotherapy could be overcome.

Rhoifoloside; Apigenin 7-O-neohesperidoside; Apigenin-7-O-rhamnoglucoside

7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(4-hydroxyphenyl)chromen-4-one

578.52

C27H30O14

CC1C(C(C(C(O1)OC2C(C(C(OC2OC3=CC(=C4C(=C3)OC(=CC4=O)C5=CC=C(C=C5)O)O)CO)O)O)O)O)O

InChI=1S/C27H30O14/c1-10-20(32)22(34)24(36)26(37-10)41-25-23(35)21(33)18(9-28)40-27(25)38-13-6-14(30)19-15(31)8-16(39-17(19)7-13)11-2-4-12(29)5-3-11/h2-8,10,18,20-30,32-36H,9H2,1H3/t10-,18+,20-,21+,22+,23-,24+,25+,26-,27+/m0/s1

RPMNUQRUHXIGHK-PYXJVEIZSA-N

916.5±65.0 °C at 760 mmHg

>98%

1.69g/cm3

Yellow powder

anti-inflammatory; anti-cancer

Yellow

Powder

25 mg