Protopine hydrochloride

For Research Use Only.
Category
Alkaloids
Cat.No.
NP0289
CAS
6164-47-2
Product Name
Protopine hydrochloride
Structure

Product Details

Description
Protopine is a benzylisoquinoline alkaloid occurring in opium poppy, Corydalis tubers and other plants of the family papaveraceae, like Fumaria officinalis. It has been found to inhibit histamine H1 receptors and platelet aggregation, and acts as an analgesic..
Synonyms
Protopine (hydrochloride); Protopine HCl; 7,13a-Secoberbin-13a-one, 7-methyl-2,3:9,10-bis(methylenedioxy)-, hydrochloride
IUPAC Name
15-methyl-7,9,19,21-tetraoxa-15-azapentacyclo[15.7.0.04,12.06,10.018,22]tetracosa-1(17),4,6(10),11,18(22),23-hexaen-3-one; hydrochloride
Molecular Weight
389.83
Molecular Formula
C20H20ClNO5
Canonical SMILES
CN1CCC2=CC3=C(C=C2C(=O)CC4=C(C1)C5=C(C=C4)OCO5)OCO3.Cl
InChI
InChI=1S/C20H19NO5.ClH/c1-21-5-4-13-7-18-19(25-10-24-18)8-14(13)16(22)6-12-2-3-17-20(15(12)9-21)26-11-23-17; /h2-3,7-8H,4-6,9-11H2,1H3; 1H
InChIKey
NWNVDSJZGYDVQW-UHFFFAOYSA-N
Purity
98 %.
Solubility
Slightly in water, practically not in alcohol
Appearance
Solid powder
Storage
Store at +4 °C, in dark place.
EINECS
228-196-5
Form
Powder
Hazard Class
6.1(b)
Hazard Codes
T
MDL
MFCD00236406
NACRES
NA.77
Packing Groups
III
RIDADR
1544
Risk Statements
25
RTECS
UL2000000
Safety Statements
36/37/39-45
Uses
Protopine hydrochloride may be used in the calibration curve preparation for the quantification of alkaloids from Fumaria capreolata using liquid chromatography coupled to diode array detection and electrospray ionization tandem mass spectrometry (LC-DAD-MS) and tandem mass spectrometry(MS/MS). It may also be used as an alkaloid in cytotoxicity and permeability studies carcinogenic cell lines.
WGK Germany
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