Protopine hydrochloride

Inquiry

For Research Use Only.

Category

Alkaloids

Cat.No.

NP0289

CAS

6164-47-2

Product Name

Protopine hydrochloride

Structure

Product Details

Description

Protopine is a benzylisoquinoline alkaloid occurring in opium poppy, Corydalis tubers and other plants of the family papaveraceae, like Fumaria officinalis. It has been found to inhibit histamine H1 receptors and platelet aggregation, and acts as an analgesic..

Synonyms

Protopine (hydrochloride); Protopine HCl; 7,13a-Secoberbin-13a-one, 7-methyl-2,3:9,10-bis(methylenedioxy)-, hydrochloride

IUPAC Name

15-methyl-7,9,19,21-tetraoxa-15-azapentacyclo[15.7.0.04,12.06,10.018,22]tetracosa-1(17),4,6(10),11,18(22),23-hexaen-3-one; hydrochloride

Molecular Weight

389.83

Molecular Formula

C20H20ClNO5

Canonical SMILES

CN1CCC2=CC3=C(C=C2C(=O)CC4=C(C1)C5=C(C=C4)OCO5)OCO3.Cl

InChI

InChI=1S/C20H19NO5.ClH/c1-21-5-4-13-7-18-19(25-10-24-18)8-14(13)16(22)6-12-2-3-17-20(15(12)9-21)26-11-23-17; /h2-3,7-8H,4-6,9-11H2,1H3; 1H

InChIKey

NWNVDSJZGYDVQW-UHFFFAOYSA-N

Purity

98 %.

Solubility

Slightly in water, practically not in alcohol

Appearance

Solid powder

Storage

Store at +4 °C, in dark place.

EINECS

228-196-5

Form

Powder

Hazard Class

6.1(b)

Hazard Codes

MDL

MFCD00236406

NACRES

NA.77

Packing Groups

III

RIDADR

1544

Risk Statements

RTECS

UL2000000

Safety Statements

36/37/39-45

Uses

Protopine hydrochloride may be used in the calibration curve preparation for the quantification of alkaloids from Fumaria capreolata using liquid chromatography coupled to diode array detection and electrospray ionization tandem mass spectrometry (LC-DAD-MS) and tandem mass spectrometry(MS/MS). It may also be used as an alkaloid in cytotoxicity and permeability studies carcinogenic cell lines.

WGK Germany

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