Pogostone

Phenols

NP4575

23800-56-8

Pogostone

Pogostone, isolated from the herbs of Pogostemon cablin (Blanco) Benth, possesses potent anti-bacterial and anti-fungal activities and has been used for the quality control of essential oil of Pogostemon cablin. It could inhibit both gram negative bacteria (0.098-1 600 µg/ml) and gram positive bacteria (0.098-800 µg/ml). Besides, Pogostone could exert a gastro-protective effect against gastric ulceration, and the underlying mechanism might be associated with the stimulation of PGE2, improvement of antioxidant and anti-inflammatory status, as well as preservation of NP-SH. Pogostone exhibited an immunosuppressive property by directly blocking T cell proliferation as well as altering inflammatory cytokine profile.

Dhelwangin; 4-Hydroxy-6-methyl-3-(4-methyl-1-oxopentyl)-2H-pyran-2-one

4-hydroxy-6-methyl-3-(4-methylpentanoyl)pyran-2-one

224.26

C12H16O4

CC1=CC(=C(C(=O)O1)C(=O)CCC(C)C)O

InChI=1S/C12H16O4/c1-7(2)4-5-9(13)11-10(14)6-8(3)16-12(11)15/h6-7,14H,4-5H2,1-3H3

AJFJTORMMHWKFW-UHFFFAOYSA-N

348.2±42.0 °C (760 Torr)

41-41.6°C

129.9±21.4 °C

>98%

1.185±0.06 g/cm3

Soluble in ethyl acetate, methanol, ethanol

Powder

Anti-bacterial/anti-fungal

MFCD29038190

5.27±0.50(Predicted)

Pogostone is a useful research chemical.