Description
Piperine (1-Piperoylpiperidine) is an alkaloid isolated from black pepper, activating transient receptor potential vanilloid type 1 receptor (TRPV1; EC50 = 38 µM) and modulates GABAA receptors (EC50s = 43-60 µM). It is used in some traditional medicines. Piperine is used as a spicy raw material in the food industry and has a sterilization effect.
Synonyms
(2E,4E)-5-(1,3-benzodioxol-5-yl)-1-piperidin-1-ylpenta-2,4-dien-1-one
Molecular Formula
C17H19NO3
Canonical SMILES
C1CCN(CC1)C(=O)C=CC=CC2=CC3=C(C=C2)OCO3
InChI
InChI=1S/C17H19NO3/c19-17(18-10-4-1-5-11-18)7-3-2-6-14-8-9-15-16(12-14)21-13-20-15/h2-3,6-9,12H,1,4-5,10-11,13H2/b6-2+,7-3+
InChIKey
MXXWOMGUGJBKIW-YPCIICBESA-N
Boiling Point
498.524 °C at 760 mmHg
Solubility
40 mg/L (18 °C)
Appearance
Off-white to pale yellow solid
Application
Ingredient of health care products.
Storage
Sealed in dry, Room Temperature
Refractive Index
1.6846 (20°C)
Stability
Stable. Incompatible with strong oxidizing agents.