Pinusolide

Inquiry

For Research Use Only.

Category

Diterpenoids

Cat.No.

NP1365

CAS

31685-80-0

Product Name

Pinusolide

Structure

Product Details

Description

Pinusolide is a natural diterpenoid found in the barks of Biota orientalis L, it is a potent and specific PAF antagonist. Pinusolide and 15-MPA protect neuronal cells from STS-induced apoptosis, probably by preventing the increase in [Ca(2+)]i and cellular oxidation caused by STS which indicates that they could be used to treat neurodegenerative diseases.

Synonyms

methyl (1S,4aR,5S,8aR)-1,4a-dimethyl-6-methylidene-5-[2-(2-oxo-2,5-dihydrofuran-3-
yl)ethyl]decahydronaphthalene-1-carboxylate

IUPAC Name

methyl (1S,4aR,5S,8aR)-1,4a-dimethyl-6-methylidene-5-[2-(5-oxo-2H-furan-4-yl)ethyl]-3,4,5,7,8,8a-hexahydro-2H-naphthalene-1-carboxylate

Molecular Weight

346.5

Molecular Formula

C21H30O4

Canonical SMILES

CC12CCCC(C1CCC(=C)C2CCC3=CCOC3=O)(C)C(=O)OC

InChI

InChI=1S/C21H30O4/c1-14-6-9-17-20(2,11-5-12-21(17,3)19(23)24-4)16(14)8-7-15-10-13-25-18(15)22/h10,16-17H,1,5-9,11-13H2,2-4H3/t16-,17+,20+,21-/m0/s1