Description
Pinostrobin, which can be extracted from the herbs of Cajanus cajan, may be responsible for the anti-hemorrhagic and analgesic activity (peripheral analgesic activity) of Renealmia alpinia. It leads to depolarisation of the cell potential of endothelial cells. Pinostrobin was able to exert a neuroprotective effect against Aβ(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative damage and calcium overload, as well as suppressing the mitochondrial pathway of cellular apoptosis. Besides, Pinostrobin (50mg/kg/dose) possesses definite therapeutical effect in the development of lesion score.
Synonyms
(S)-2,3-dihydro-5-hydroxy-7-methoxy-2-phenyl-4H-1-benzopyran-4-one; (S)-2,3-dihydro-5-hydroxy-7-methoxy-2-phenyl-4-benzopyrone; 5-Hydroxy-7-methoxy-2-phenyl-chroman-4-one; 5-Hydroxy-7-methoxyflavanone; (2S)-2,3-Dihydro-5-hydroxy-7-methoxy-2-phenyl-4H-1-benzopyran-4-one; 2,3-Dihydro-5-hydroxy-7-methoxy-2-phenyl-4H-1-benzopyran-4-one; 2-Phenyl-5-hydroxy-7-methoxy-2,3-dihydro-4H-1-benzopyran-4-one
IUPAC Name
5-hydroxy-7-methoxy-2-phenyl-2,3-dihydrochromen-4-one
Molecular Formula
C16H14O4
Canonical SMILES
COC1=CC(=C2C(=O)CC(OC2=C1)C3=CC=CC=C3)O
InChI
InChI=1S/C16H14O4/c1-19-11-7-12(17)16-13(18)9-14(20-15(16)8-11)10-5-3-2-4-6-10/h2-8,14,17H,9H2,1H3
InChIKey
ORJDDOBAOGKRJV-UHFFFAOYSA-N
Boiling Point
494.9±45.0°C (Predicted)
Density
1.284±0.06 g/cm3(Predicted)
Application
Anti-hemorrhagic/analgesic
Definition
ChEBI: A monohydroxyflavanone that is (2S)-flavanone substituted by a hydroxy group at position 5 and a methoxy group at position 7 respectively.