Peiminine

For Research Use Only.
Category
Alkaloids
Cat.No.
NP0526
CAS
18059-10-4
Product Name
Peiminine
Structure

Product Details

Description
Peiminine is an alkaloid isolated from Fritillaria. Peiminine and DXS significantly reduced alveolar inflammation and pulmonary interstitial inflammation in rats with bleomycin-induced lung injury. Peiminine inhibits lung inflammation and pulmonary fibrosis in a rat model of bleomycin-induced lung injury, by reducing circulating IFN-γ levels and inhibiting signal transduction pathways involving TGF-β, CTGF, ERK1/2, NF-κB and FasL.
Synonyms
Verticinone; Raddeanine
IUPAC Name
(1R,2S,6S,9S,10S,11S,14S,15S,18S,20S,23R,24S)-10,20-dihydroxy-6,10,23-trimethyl-4-azahexacyclo[12.11.0.02,11.04,9.015,24.018,23]pentacosan-17-one
Molecular Weight
429.64
Molecular Formula
C27H43NO3
Canonical SMILES
CC1CCC2C(C3CCC4C(C3CN2C1)CC5C4CC(=O)C6C5(CCC(C6)O)C)(C)O
InChI
InChI=1S/C27H43NO3/c1-15-4-7-25-27(3,31)21-6-5-17-18(20(21)14-28(25)13-15)11-22-19(17)12-24(30)23-10-16(29)8-9-26(22,23)2/h15-23,25,29,31H,4-14H2,1-3H3/t15-,16-,17+,18+,19-,20-,21-,22-,23+,25-,26+,27-/m0/s1
InChIKey
IQDIERHFZVCNRZ-YUYPDVIUSA-N
Purity
>98%
Appearance
Powder
Application
moistening lung
Color
Orange
Form
Powder
Packaging
25 mg
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