Parthenolide

Inquiry

For Research Use Only.

Category

Sesquiterpenoids

Cat.No.

NP5783

CAS

20554-84-1

Product Name

Parthenolide

Structure

Product Details

Description

(-)-Parthenolide is a sesquiterpene lactone which occurs naturally in the plant feverfew (Tanacetum parthenium) and also promotes the ubiquitination of MDM2 and activates p53 cellular functions.

Synonyms

NSC-157035; NSC 157035; NSC157035

IUPAC Name

(1S,2R,4R,7E,11S)-4,8-dimethyl-12-methylidene-3,14-dioxatricyclo[9.3.0.02,4]tetradec-7-en-13-one

Molecular Weight

248.32

Molecular Formula

C15H20O3

Canonical SMILES

CC1=CCCC2(C(O2)C3C(CC1)C(=C)C(=O)O3)C

InChI

InChI=1S/C15H20O3/c1-9-5-4-8-15(3)13(18-15)12-11(7-6-9)10(2)14(16)17-12/h5,11-13H,2,4,6-8H2,1,3H3/b9-5+/t11-,12-,13+,15+/m0/s1

InChIKey

KTEXNACQROZXEV-PVLRGYAZSA-N

Boiling Point

394.1°C at 760 mmHg

Melting Point

112-118°C

Purity

>98%

Density

1.13 g/cm3

Solubility

Soluble in DMSO (100 mg/ml), Ethanol (20 mg/ml), Dichloromethane

Appearance

White to Light Yellow Crystalline Powder

Application

5-HT antagonist; anti-tumor; anti-cancer; antimycobacterial; anti-inflammatory

Storage

Store at -20°C

Form

Powder

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