Orsellinic acid

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For Research Use Only.

Category

Phenols

Cat.No.

NP4627

CAS

480-64-8

Product Name

Orsellinic acid

Structure

Product Details

Description

Orsellinic acid is from Chaetomium globosum endophytic. Orsellinic acid can block platelet activating factor (PAF)-mediated neuronal apoptosis without affecting G-protein coupled receptor (PAFR)-mediated neuroprotection, and it can effectively attenuate PAFR-independent neuronal apoptosis. It is a novel benzoquinone ring precursor for antroquinonol and 4-acetylantroquinonol B. It is formed from acetyl-coenzyme Q (CoQ) and malonyl-CoA via polyketide pathway.

Synonyms

o-Orsellinic acid; 4,6-Dihydroxy-o-toluic acid

IUPAC Name

2,4-dihydroxy-6-methylbenzoic acid

Molecular Weight

168.15

Molecular Formula

C8H8O4

Canonical SMILES

CC1=CC(=CC(=C1C(=O)O)O)O

InChI

InChI=1S/C8H8O4/c1-4-2-5(9)3-6(10)7(4)8(11)12/h2-3,9-10H,1H3,(H,11,12)

InChIKey

AMKYESDOVDKZKV-UHFFFAOYSA-N

Boiling Point

257.07°C at 760 mmHg

Melting Point

176°C

Purity

99.0%

Density

1.3037 g/cm3

Solubility

Soluble in water, DMSO or 100% ethanol.

Appearance

Colorless Acicular Crystals

Storage

Store at -20°C

Color

White to Pale Gray

Definition

ChEBI: A dihydroxybenzoic acid that is 2,4-dihydroxybenzoic acid in which the hydrogen at position 6 is replaced by a methyl group.

Form

Solid

MDL

MFCD00210536

pKa

pK (25°) 3.90

Refractive Index

1.5090 (estimate)

Stability

Hygroscopic

Uses

Orsellinic acid is a benzoic acid compound shown to block PAF-mediated neuronal apoptosis.

Water Solubility

Soluble in water, dimethyl sulfoxide or 100% ethanol.

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