Nevirapine

Inquiry

For Research Use Only.

Category

Impurities

Cat.No.

NP3489

CAS

129618-40-2

Product Name

Nevirapine

Structure

Product Details

Description

Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS.

Synonyms

BI-RG-587; BIRG 0587; BIRG587; HSDB 7164; Nevirapine; NSC 641530; NVP; Brand name: Viramune Viramune XR.

IUPAC Name

2-cyclopropyl-7-methyl-2,4,9,15-tetrazatricyclo[9.4.0.03,8]pentadeca-1(11),3,5,7,12,14-hexaen-10-one

Molecular Weight

266.3

Molecular Formula

C15H14N4O

Canonical SMILES

CC1=C2C(=NC=C1)N(C3=C(C=CC=N3)C(=O)N2)C4CC4

InChI

InChI=1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,20)

InChIKey

NQDJXKOVJZTUJA-UHFFFAOYSA-N

Boiling Point

415.4±45.0 °C at 760 mmHg

Melting Point

239-249 °C

Flash Point

205.0±28.7 °C

Purity

>98%

Density

1.4±0.1 g/cm3

Solubility

In Vitro:
DMSO: 14.29 mg/mL (53.66 mM; Need ultrasonic)
In Vivo:
1.Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 1.43 mg/mL (5.37 mM); Clear solution
2.Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline
Solubility: ≥ 1.43 mg/mL (5.37 mM); Clear solution

Appearance

White to Pale Yellow Solid

Storage

Powder:
-20°C: 3 years
4°C: 2 years
In solvent:
-80°C: 6 months
-20°C: 1 month

Vapor Pressure

0.0±1.0 mmHg at 25°C

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