Naphtho[1,2-b]furan-2(3H)-one,3a,4,5,5a,6,7,9a,9b-octahydro-6-hydroxy-5a,9-dimethyl-3-methylene-,(3aS,5aR,6R,9aS,9bS)-

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For Research Use Only.

Category

Sesquiterpene

Cat.No.

NP5549

CAS

4290-13-5

Product Name

Naphtho[1,2-b]furan-2(3H)-one,3a,4,5,5a,6,7,9a,9b-octahydro-6-hydroxy-5a,9-dimethyl-3-methylene-,(3aS,5aR,6R,9aS,9bS)-

Structure

Product Details

Description

Santamarine, which is found in the root of Dolomiaea souliei (Franch.) Shih, induced apoptosis of L1210 cells via activation of caspase 3. It also exhibits significant anticancer activity in vitro. The inhibitory effects of Santamarine on L1210 cells is cytotoxic rather than just cytostatic.

Synonyms

SANTAMARIN; (3aS)-2,3,3aβ,4,5,5a,6,7,9aβ,9bα-Decahydro-6α-hydroxy-5aα,9-dimethyl-3-methylenenaphtho[1,2-b]furan-2-one; Balchanin; (3aS,5aR,6R,9aS,9bS)-6-hydroxy-5a,9-dimethyl-3-methylene-4,5,6,7,9a,9b-hexahydro-3aH-benzo[g]benzofuran-2-one; (3aS,5aR,6R,9aS,9bS)-6-hydroxy-5a,9-dimethyl-3-methylidene-4,5,6,7,9a,9b-hexahydro-3aH-benzo[g][1]benzofuran-2-one

Molecular Weight

248.3

Molecular Formula

C15H20O3

Boiling Point

415.6±45.0 °C(Predicted)

Melting Point

142 °C

Purity

>98%

Density

1.17±0.1 g/cm3(Predicted)

Solubility

Chloroform (Slightly), methanol (Slightly)

Appearance

Powder

Application

Anticancer

Storage

-20°C Freezer

Color

White to Off-White

Definition

ChEBI: A sesquiterpene lactone of the eudesmanolide group.

Form

Solid

pKa

14.54±0.60(Predicted)

Uses

Santamarine is a sesquiterpene lactone shows anticancer properties by inhibiting proliferation and inducing apoptosis.

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* Service & Products of Interested: [Sesquiterpene] Naphtho[1,2-b]furan-2(3H)-one,3a,4,5,5a,6,7,9a,9b-octahydro-6-hydroxy-5a,9-dimethyl-3-methylene-,(3aS,5aR,6R,9aS,9bS)- (4290-13-5)
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