N-Methylcytisine

Alkaloids

NP0556

486-86-2

N-Methylcytisine

Nicotinic receptors of acetylcholine in the CNS.Cytisine and N-methylcytisine have high affinity (KD = 50 nM) to nAChR from squid optical ganglia. N,N-dimethylcytisine did not show high affinity to this receptor. In the case of nAChR from T. marmorata, cytisine was the only effective inhibitor of 14C-tubocurarine specific binding (Ki = 700 nM). N-methyl- and N,N-dimethylcytisine did not displace 14C-tubocurarine at a concentration of 0.1 mM. The results obtained indicate that there are some differences in the structure of nAChR binding sites from squid and T. marmorata optical ganglia.

(1R,9S)-11-methyl-7,11-diazatricyclo[7.3.1.02,7]trideca-2,4-dien-6-one

(1R,9S)-11-methyl-7,11-diazatricyclo[7.3.1.02,7]trideca-2,4-dien-6-one

204.27

C12H16N2O

CN1CC2CC(C1)C3=CC=CC(=O)N3C2

InChI=1S/C12H16N2O/c1-13-6-9-5-10(8-13)11-3-2-4-12(15)14(11)7-9/h2-4,9-10H,5-8H2,1H3/t9-,10+/m0/s1

CULUKMPMGVXCEI-VHSXEESVSA-N

400.8 °C at 760 mmHg

> 98 %

1.21 g/cm³

White cryst.

Antiarrhythmia

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