N-Methylcytisine

For Research Use Only.
Category
Alkaloids
Cat.No.
NP0556
CAS
486-86-2
Product Name
N-Methylcytisine
Structure

Product Details

Description
Nicotinic receptors of acetylcholine in the CNS.Cytisine and N-methylcytisine have high affinity (KD = 50 nM) to nAChR from squid optical ganglia. N,N-dimethylcytisine did not show high affinity to this receptor. In the case of nAChR from T. marmorata, cytisine was the only effective inhibitor of 14C-tubocurarine specific binding (Ki = 700 nM). N-methyl- and N,N-dimethylcytisine did not displace 14C-tubocurarine at a concentration of 0.1 mM. The results obtained indicate that there are some differences in the structure of nAChR binding sites from squid and T. marmorata optical ganglia.
Synonyms
(1R,9S)-11-methyl-7,11-diazatricyclo[7.3.1.02,7]trideca-2,4-dien-6-one
IUPAC Name
(1R,9S)-11-methyl-7,11-diazatricyclo[7.3.1.02,7]trideca-2,4-dien-6-one
Molecular Weight
204.27
Molecular Formula
C12H16N2O
Canonical SMILES
CN1CC2CC(C1)C3=CC=CC(=O)N3C2
InChI
InChI=1S/C12H16N2O/c1-13-6-9-5-10(8-13)11-3-2-4-12(15)14(11)7-9/h2-4,9-10H,5-8H2,1H3/t9-,10+/m0/s1
InChIKey
CULUKMPMGVXCEI-VHSXEESVSA-N
Boiling Point
400.8 °C at 760 mmHg
Purity
> 98 %
Density
1.21 g/cm3
Appearance
White cryst.
Application
Antiarrhythmia
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