Moronic acid

Terpenes

NP6250

6713-27-5

Moronic acid

Moronic acid isolated from the herbs of Rhus chinensis. It shows oral therapeutic efficacy in HSV-infected mice and possessed novel anti-HSV activity.

Moronic acid;6713-27-5;3-Oxoolean-18-en-28-oic acid;(4aS,6aR,6aR,6bR,8aR,12aR,14aS)-2,2,6a,6b,9,9,12a-heptamethyl-10-oxo-4,5,6,6a,7,8,8a,11,12,13,14,14a-dodecahydro-3H-picene-4a-carboxylic acid;XW8W7HC4JK;MLS000563430;CHEBI:30815;Moronicacid;SMR000232278;AMBRONIC ACID;UNII-XW8W7HC4JK;(+)-MORONIC ACID;MLS000728508;SCHEMBL324972;3-Oxoolean-18-en-28-oic acid; (+)-Moronic acid; Ambronic acid;CHEMBL472646;cid_489941;BDBM54263;DTXSID30891948;HY-N3242;MFCD11113464;AKOS032948476;FS-8943;LMPR0106150002;NCGC00247448-01;NCGC00247448-02;DA-55640;CS-0023704;M2610;OLEAN-18-EN-28-OIC ACID, 3-OXO-;Q6913266;(4aS,6aR,6aR,6bR,8aR,12aR,14aS)-10-keto-2,2,6a,6b,9,9,12a-heptamethyl-4,5,6,6a,7,8,8a,11,12,13,14,14a-dodecahydro-3H-picene-4a-carboxylic acid;(4aS,6aR,6aR,6bR,8aR,12aR,14aS)-2,2,6a,6b,9,9,12a-heptamethyl-10-oxidanylidene-4,5,6,6a,7,8,8a,11,12,13,14,14a-dodecahydro-3H-picene-4a-carboxylic acid;(4aS,6aR,6bR,8aR,12aR,12bR,14aS)-2,2,6a,6b,9,9,12a-heptamethyl-10-oxo-2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14,14a-icosahydropicene-4a-carboxylic acid;(4aS,6aR,6bR,8aR,12aR,12bR,14aS)-2,2,6a,6b,9,9,12a-Heptamethyl-10-oxo-3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14,14a-octadecahydro-2H-picene-4a-carboxylic acid;

(4aS,6aR,6aR,6bR,8aR,12aR,14aS)-2,2,6a,6b,9,9,12a-heptamethyl-10-oxo-4,5,6,6a,7,8,8a,11,12,13,14,14a-dodecahydro-3H-picene-4a-carboxylic acid

454.68

C30H46O3

C[C@]12[C@]3([C@@](CC[C@]1([H])[C@@]4([C@@](C(C)(C(CC4)=O)C)([H])CC2)C)([H])C5=CC(C)(C)CC[C@@]5(CC3)C(O)=O)C

InChI=1S/C30H46O3/c1-25(2)14-16-30(24(32)33)17-15-28(6)19(20(30)18-25)8-9-22-27(5)12-11-23(31)26(3,4)21(27)10-13-29(22,28)7/h18-19,21-22H,8-17H2,1-7H3,(H,32,33)/t19-,21+,22-,27+,28-,29-,30+/m1/s1

UMYJVVZWBKIXQQ-QALSDZMNSA-N

212 °C(dec.)

98%

Solid

anti-HIV;anti-HSV;anti-EBV

ChEBI: A pentacyclic triterpenoid that is olean-18-ene substituted at position 3 by an oxo group and position 28 by a carboxy group.

Moronic Acid and its derivatives can have antidiabetic activity by inhibiting PTP-1B. Moronic Acid is also shown sustained antidiabetic and antihyperglycemic action possibly mediated by an insulin sensitization in rat models.