Mifepristone

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For Research Use Only.

Category

Impurities

Cat.No.

NP3298

CAS

84371-65-3

Product Name

Mifepristone

Structure

Product Details

Description

Mifepristone is a progesterone receptor antagonist with partial agonist activity. It is an abortifacient.

Synonyms

(11β,17β)-11-[4-(Dimethylamino)phenyl]-17-hydroxy-17-(1-propyn-1-yl)estra-4,9-dien-3-one; RU-486; RU-38486; Mifegyne; Mifeprex; Mifestone; VGX 410

IUPAC Name

(8S,11R,13S,14S,17S)-11-[4-(dimethylamino)phenyl]-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one

Molecular Weight

429.60

Molecular Formula

C29H35NO2

Canonical SMILES

CC#CC1(CCC2C1(CC(C3=C4CCC(=O)C=C4CCC23)C5=CC=C(C=C5)N(C)C)C)O

InChI

InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1

InChIKey

VKHAHZOOUSRJNA-GCNJZUOMSA-N

Boiling Point

628.6±55.0 °C | Condition: Press: 760 Torr

Melting Point

195-198°C

Purity

> 95%

Density

1.18±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr

Solubility

DMSO: ≥ 59 mg/mL

Appearance

Yellow crystalline powder

Application

Mifepristone is used as an abortifacient in the first months of pregnancy, and in smaller doses as an emergency contraceptive. It has occasionally been used in refractory Cushing's Syndrome. It is used in combination with misoprostol for the oral induction of first trimester abortions. It induces growth arrest, caspase activation, and cell death in anti-estrogen-resistant breast cancer cells, which indicats the effectiveness of PR antagonism as a novel approach to treatment of select cancers.

Shelf Life

2 month in rt, long time

Storage

2-8°C

Form

Powder

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