Methyl orsellinate

Phenols

NP4785

3187-58-4

Methyl orsellinate

Methyl orsellinate is purified from the herbs of Dianella ensifolia (L.) DC.2. Methyl orsellinate exhibits antifungal activity. It can inhibit PTP1B activity with 50% inhibitory concentration values of 277 +/- 8.6 microM, and the selective inhibition of PTP1B has been widely recognized as a potential drug target for the treatment of type 2 diabetes and obesity. Methyl orsellinate is a phytotoxic compound, and it can cause significant inhibition of radicle growth of Amaranthus hypochondriacus and Echinochloa crus-galli, interact with bovine-brain calmodulin and inhibit the activation of the calmodulin-dependent enzyme cAMP phosphodiesterase.

methyl 2,4-dihydroxy-6-methylbenzoate

182.18

C9H10O4

CC1=CC(=CC(=C1C(=O)OC)O)O

InChI=1S/C9H10O4/c1-5-3-6(10)4-7(11)8(5)9(12)13-2/h3-4,10-11H,1-2H3

NCCWCZLEACWJIN-UHFFFAOYSA-N

339 °C

141-142 °C

138 °C

0.98

1.296 g/cm3

Powder

2-8°C

MFCD00184668

8.27±0.23(Predicted)

Methyl 2,4-Dihydroxy-6-methylbenzoate is a useful synthetic intermediate in the synthesis of Grifolic Acid (G786500); a selective partial GPR120 agonist.Grifolic Acid induces ERK and [Ca2+]i responses in cells expressing GPR120, but has no effects on those expressing GPR40.