Methyl orsellinate

For Research Use Only.
Category
Phenols
Cat.No.
NP4785
CAS
3187-58-4
Product Name
Methyl orsellinate
Structure

Product Details

Description
Methyl orsellinate is purified from the herbs of Dianella ensifolia (L.) DC.2. Methyl orsellinate exhibits antifungal activity. It can inhibit PTP1B activity with 50% inhibitory concentration values of 277 +/- 8.6 microM, and the selective inhibition of PTP1B has been widely recognized as a potential drug target for the treatment of type 2 diabetes and obesity. Methyl orsellinate is a phytotoxic compound, and it can cause significant inhibition of radicle growth of Amaranthus hypochondriacus and Echinochloa crus-galli, interact with bovine-brain calmodulin and inhibit the activation of the calmodulin-dependent enzyme cAMP phosphodiesterase.
Synonyms
methyl 2,4-dihydroxy-6-methylbenzoate
Molecular Weight
182.18
Molecular Formula
C9H10O4
Canonical SMILES
CC1=CC(=CC(=C1C(=O)OC)O)O
InChI
InChI=1S/C9H10O4/c1-5-3-6(10)4-7(11)8(5)9(12)13-2/h3-4,10-11H,1-2H3
InChIKey
NCCWCZLEACWJIN-UHFFFAOYSA-N
Boiling Point
339 °C
Melting Point
141-142 °C
Flash Point
138 °C
Purity
0.98
Density
1.296 g/cm3
Appearance
Powder
Storage
2-8°C
MDL
MFCD00184668
pKa
8.27±0.23(Predicted)
Uses
Methyl 2,4-Dihydroxy-6-methylbenzoate is a useful synthetic intermediate in the synthesis of Grifolic Acid (G786500); a selective partial GPR120 agonist.Grifolic Acid induces ERK and [Ca2+]i responses in cells expressing GPR120, but has no effects on those expressing GPR40.
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