Description
Memantine is the first in a novel class of Alzheimer's disease medications acting on the glutamatergic system by blocking NMDA receptors.It is also a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively.
Synonyms
3,5-Dimethyltricyclo[3.3.1.13,7]decan-1-amine Hydrochloride; 3,5-Dimethyl-1- adamantanamine; 1-Amino-3,5-dimethyladamantane Hydrochloride; Akatinol; Axura; Ebix; Ebixia; Ebixza; NSC 102290; Namenda; SUN Y7017; Tocris
IUPAC Name
3,5-dimethyladamantan-1-amine;hydrochloride
Molecular Formula
C12H21N.HCl
Canonical SMILES
CC12CC3CC(C1)(CC(C3)(C2)N)C.Cl
InChI
InChI=1S/C12H21N.ClH/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10;/h9H,3-8,13H2,1-2H3;1H
InChIKey
LDDHMLJTFXJGPI-UHFFFAOYSA-N
Melting Point
>300°C (sublimes)
Solubility
29.4 [ug/mL] (The mean of the results at pH 7.4)
Appearance
White crystalline powder
Application
Antiparkinson Agents