Magnolin

Inquiry

For Research Use Only.

Category

Lignans

Cat.No.

NP4206

CAS

31008-18-1

Product Name

Magnolin

Structure

Product Details

Description

Magnolin is a major pharmacologically active ingredient derived from Shin-i, the dried flower buds of Magnolia fargesii (Magnoliaceae) that has been used for the treatment of empyema, nasal congestion, sinusitis, and allergic rhinitis. Magnolin inhibits the Ras/ERKs/RSK2 signaling axis by targeting the active pocket of ERK1 and ERK2 with IC50s of 87 nM and 16.5 nM, respectively.

Synonyms

(1S,3aR,4S,6aR)-1-(3,4-Dimethoxyphenyl)tetrahydro-4-(3,4,5-trimethoxyphenyl)-1H,3H-furo[3,4-c]furan; 1H,3H-Furo[3,4-c]furan, 1-(3,4-dimethoxyphenyl)tetrahydro-4-(3,4,5-trimethoxyphenyl)-, [1S-(1α,3aα,4α,6aα)]-; 1H,3H-Furo[3,4-c]furan, 1α-(3,4-dimethoxyphenyl)-3aα,4,6,6aα-tetrahydro-4α-(3,4,5-trimethoxyphenyl)-, (+)-; (+)-Magnolin; Medioresinol dimethyl ether

IUPAC Name

(3S,3aR,6S,6aR)-3-(3,4-dimethoxyphenyl)-6-(3,4,5-trimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan

Molecular Weight

416.46

Molecular Formula

C23H28O7

Canonical SMILES

O(C1=CC=C(C=C1OC)C2OCC3C(OCC23)C4=CC(OC)=C(OC)C(OC)=C4)C

InChI

InChI=1S/C23H28O7/c1-24-17-7-6-13(8-18(17)25-2)21-15-11-30-22(16(15)12-29-21)14-9-19(26-3)23(28-5)20(10-14)27-4/h6-10,15-16,21-22H,11-12H2,1-5H3/t15-,16-,21+,22+/m0/s1

InChIKey

MFIHSKBTNZNJIK-RZTYQLBFSA-N

Boiling Point

536.9±50.0 °C at 760 mmHg

Melting Point

91.4-92.9 °C

Purity

98%

Density

1.178±0.06 g/cm3

Solubility

DMSO