Lyoniresinol

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For Research Use Only.

Size	Price	Stock	Quantity
1 mg	$469	In stock

Category

Lignans

Cat.No.

NP3922

CAS

14464-90-5

Product Name

Lyoniresinol

Structure

Product Details

Description

Lyoniresinol, a natural lignan isolated from the root of Vitex negundo,is one of the eight lignans purified from methanol which has robust tyrosinase inhibitory capacity. Lyoniresinol exhibits the activity of antioxidative, and it decreases tyrosinase activity and melanin biosynthesis in B16F10 cells by activating ERK signaling, which downregulates MITF, tyrosinase, but not TRP-1 and TRP-2 protein expression, it can perhaps be incorporated into clinical dermatologic use as a skin lightening agent.

Synonyms

(1S)-1α-(3,5-Dimethoxy-4-hydroxyphenyl)-6,8-dimethoxy-7-hydroxy-1,2,3,4-tetrahydronaphthalene-2β,3α-dimethanol

IUPAC Name

(6R,7R,8S)-8-(4-hydroxy-3,5-dimethoxyphenyl)-6,7-bis(hydroxymethyl)-1,3-dimethoxy-5,6,7,8-tetrahydronaphthalen-2-ol

Molecular Weight

420.5

Molecular Formula

C22H28O8

Canonical SMILES

COC1=CC(=CC(=C1O)OC)C2C(C(CC3=CC(=C(C(=C23)OC)O)OC)CO)CO

InChI

InChI=1S/C22H28O8/c1-27-15-7-12(8-16(28-2)20(15)25)18-14(10-24)13(9-23)5-11-6-17(29-3)21(26)22(30-4)19(11)18/h6-8,13-14,18,23-26H,5,9-10H2,1-4H3/t13-,14-,18+/m0/s1

InChIKey

ZDVZKBOFCHOPLM-SUNYJGFJSA-N

Boiling Point

617.6±55.0 °C(Predicted)

Melting Point

170.7-171.0 °C

Purity

>98%

Density

1.272±0.06 g/cm3(Predicted)

Appearance

Powder

Application

anti-melanogenic; anti-oxidant

EINECS

200-258-5

pKa

10.05±0.40(Predicted)

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