Loureirin B

For Research Use Only.
Category
Chalcones
Cat.No.
NP0990
CAS
119425-90-0
Product Name
Loureirin B
Structure

Product Details

Description
Loureirin B, isolated from the herbs of Dracaena cochinchinensis, is a channel blocker of Kv1.3 by interacting with amino acid residues in its selective filter region. Direct inhibition of Kv1.3 in T cells by SD and Loureirin B might be the cellular and molecular basis of SD-mediated immunosuppression. Loureirin B could evoke the elevation of [Ca(2+)](i) in a dose-dependent manner. Loureirin B is also the effective component in dragon's blood modulating sodium currents in trigeminal ganglion neurons.
Synonyms
1-Propanone,1-(4-hydroxyphenyl)-3-(2,4,6-triMethoxyphenyl)
IUPAC Name
1-(4-hydroxyphenyl)-3-(2,4,6-trimethoxyphenyl)propan-1-one
Molecular Weight
316.35
Molecular Formula
C18H20O5
Canonical SMILES
COC1=CC(=C(C(=C1)OC)CCC(=O)C2=CC=C(C=C2)O)OC
InChI
InChI=1S/C18H20O5/c1-21-14-10-17(22-2)15(18(11-14)23-3)8-9-16(20)12-4-6-13(19)7-5-12/h4-7,10-11,19H,8-9H2,1-3H3
InChIKey
ZPFRAPVRYLGYEC-UHFFFAOYSA-N
Purity
>98%
Appearance
White powder
Application
Analgesic/anti-inflammatory
Form
Powder
Packaging
250 mg
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