Loureirin B

Chalcones

NP0990

119425-90-0

Loureirin B

Loureirin B, isolated from the herbs of Dracaena cochinchinensis, is a channel blocker of Kv1.3 by interacting with amino acid residues in its selective filter region. Direct inhibition of Kv1.3 in T cells by SD and Loureirin B might be the cellular and molecular basis of SD-mediated immunosuppression. Loureirin B could evoke the elevation of [Ca(2+)](i) in a dose-dependent manner. Loureirin B is also the effective component in dragon's blood modulating sodium currents in trigeminal ganglion neurons.

1-Propanone,1-(4-hydroxyphenyl)-3-(2,4,6-triMethoxyphenyl)

1-(4-hydroxyphenyl)-3-(2,4,6-trimethoxyphenyl)propan-1-one

316.35

C18H20O5

COC1=CC(=C(C(=C1)OC)CCC(=O)C2=CC=C(C=C2)O)OC

InChI=1S/C18H20O5/c1-21-14-10-17(22-2)15(18(11-14)23-3)8-9-16(20)12-4-6-13(19)7-5-12/h4-7,10-11,19H,8-9H2,1-3H3

ZPFRAPVRYLGYEC-UHFFFAOYSA-N

>98%

White powder

Analgesic/anti-inflammatory

Powder

250 mg