Liriodenine

Inquiry

For Research Use Only.

Category

Alkaloids

Cat.No.

NP0425

CAS

475-75-2

Product Name

Liriodenine

Structure

Product Details

Description

Liriodenine, which can be isolated from the barks of Liriodendron chinense (Hemsl.) Sarg, exhibits potent antitumor activities in laryngocarcinoma HEp-2 cells, in vitro and in vivo, via the upregulation of p53 expression. It inhibits progression of the CAOV-3 cell cycle in S phase.

Synonyms

8H-Benzo[G]-1,3-benzodioxolo[6,5,4-de]quinolin-8-one; Micheline b; Noraporphin-7-one, 4,5,6,6A-tetradehydro-1,2-(methylenedioxy)-; Nsc93681; Oxoushinsunin; Oxoushinsunine; Spermatheridin

IUPAC Name

3,5-dioxa-11-azapentacyclo[10.7.1.02,6.08,20.014,19]icosa-1(20),2(6),7,9,11,14,16,18-octaen-13-one

Molecular Weight

275.3

Molecular Formula

C17H9NO3

Canonical SMILES

C1OC2=C(O1)C3=C4C(=C2)C=CN=C4C(=O)C5=CC=CC=C53

InChI

InChI=1S/C17H9NO3/c19-16-11-4-2-1-3-10(11)14-13-9(5-6-18-15(13)16)7-12-17(14)21-8-20-12/h1-7H,8H2

InChIKey

MUMCCPUVOAUBAN-UHFFFAOYSA-N

Melting Point

282°C

Purity

>98%

Appearance

Yellow powder

Application

Antitumor

Definition

ChEBI: An oxoaporphine alkaloid that is 4,5,6,6a-tetradehydronoraporphin-7-one substituted by a methylenedioxy group across positions 1 and 2. It is isolated from Annona glabra and has been shown to exhibit antimicrobial and cytotoxic activities.

Form

Powder

Uses

Liriodenine is an isoquinoline alkaloid found in extracts of medicinal Asian vegetation such as Michelia alba and Liriodendron chinense.

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