Description
Licoisoflavone A, a potential MRP inhibitor, is a natural flavonoid derived from the roots of Glycyrrhiza uralensis Fisch. It inhibits lipid peroxidation with an IC50 of 7.2 μM. Licoisoflavone A and Licoisoflavone B inhibit copper-induced protein oxidative modification of mice brain homogenate in vitro.
Synonyms
2',4',5,7-Tetrahydroxy-3'-(3,3-dimethylallyl)isoflavone; 3-[2,4-Dihydroxy-3-(3-methyl-2-butenyl)phenyl]-5,7-dihydroxy-4H-1-benzopyran-4-one; Phaseoluteone; 4H-1-Benzopyran-4-one, 3-[2,4-dihydroxy-3-(3-methyl-2-buten-1-yl)phenyl]-5,7-dihydroxy-; 2',4',5,7-Tetrahydroxy-3'-(3,3-dimethylallyl)isoflavone; 3'-Isopentenyl-2',4',5,7-tetrahydroxyisoflavone
IUPAC Name
3-[2,4-dihydroxy-3-(3-methylbut-2-enyl)phenyl]-5,7-dihydroxychromen-4-one
Molecular Formula
C20H18O6
Canonical SMILES
CC(=CCC1=C(C=CC(=C1O)C2=COC3=CC(=CC(=C3C2=O)O)O)O)C
InChI
InChI=1S/C20H18O6/c1-10(2)3-4-13-15(22)6-5-12(19(13)24)14-9-26-17-8-11(21)7-16(23)18(17)20(14)25/h3,5-9,21-24H,4H2,1-2H3
InChIKey
KCUZCRLRQVRBBV-UHFFFAOYSA-N
Boiling Point
635.7±55.0°C (Predicted)
Density
1.424±0.06 g/cm3 (Predicted)
Solubility
Soluble in Acetone, Chloroform, Dichloromethane, DMSO, Ethyl Acetate