Lapatinib

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For Research Use Only.

Size	Price	Stock	Quantity
1 g	$168	In stock

Category

Impurities

Cat.No.

NP3214

CAS

231277-92-2

Product Name

Lapatinib

Structure

Product Details

Description

Lapatinib, used in the form of Lapatinib Ditosylate, is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively.

Synonyms

GW-572016; GSK-572016; GSK 572016

IUPAC Name

N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine

Molecular Weight

581.06

Molecular Formula

C29H26ClFN4O4S

Canonical SMILES

CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl

InChI

InChI=1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35)

InChIKey

BCFGMOOMADDAQU-UHFFFAOYSA-N

Purity

>98%

Solubility

Yellow solid. Solubility at 25 eg C (mg/mL): 0.007 in water; 0.001 in 0.1 N HCl /Lapatinib ditoluenesulfonate monohydrate/

Application

Antineoplastic agents; protein kinase inhibitors

Form

Powder

Packaging

1 g

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